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Many animal studies on intrauterine inflammation demonstrate that ascending infection of reproductive organs or the production of proinflammatory cytokines by some stimuli in utero results in such manifestations. Melatonin, known for its primary function in maintaining circadian rhythm, is now recognized as one of the most potent antioxidant and anti\u2010inflammatory drugs. In some studies, melatonin injection in pregnant animals with intrauterine inflammation significantly reduced the number of preterm births, the severity of structural disintegration of the fetal lungs observed in bronchopulmonary dysplasia, and perinatal brain injuries with improvement in neuromotor function. These implicated benefits of melatonin in pregnant women with intrauterine inflammation seem promising in many research studies, strongly supporting the hypothesis that melatonin has antioxidative and anti\u2010inflammatory properties that can potentially be taken by pregnant women who are at risk of having intrauterine inflammation. In this review, the potential of melatonin for improving outcomes of the pregnancies with intrauterine inflammation will be discussed.<\/jats:p>","DOI":"10.1111\/aji.13402","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T15:17:49Z","timestamp":1613315869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Melatonin for the prevention of fetal injury associated with intrauterine inflammation"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-179X","authenticated-orcid":false,"given":"Jang Mee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medicine CHA University School of Medicine Pocheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Educational Competence Support Center Hanshin University Osan 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