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Recently, meta\u2010analyses have observed the effectiveness and safety of LIT in treating couples with RM. Some studies evaluated the use of LIT in recurrent implantation failure (RIF) in <jats:italic>in vitro<\/jats:italic> fertilization cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic and narrative review evaluated the data available in the literature regarding the efficacy and safety of the use of LIT. Searches in PubMed\/Medline, Embase, and Cochrane Library databases were conducted, using the following keywords: \"recurrent miscarriage,\" \"lymphocyte immunotherapy,\" and \"recurrent implantation failure\".<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This review describes the historical aspects of LIT and discusses its protocols, mechanisms of action, side effects, complications, and current evidence of the effectiveness in cases of reproductive failure. It also discusses the use of LIT during the COVID\u201019 pandemic and new immunological therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the vast majority of studies, the use of LIT for RM couples has shown an improvement in pregnancy outcomes. The most of the current studies that support the evidence are quasi\u2010experimental, with few randomized, double\u2010blind studies (Level of evidence III). However, the current evidence are not convincing for the use of LIT in RIF patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13408","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T04:46:41Z","timestamp":1614401201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Lymphocyte immunotherapy in recurrent miscarriage and recurrent implantation failure"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-9731","authenticated-orcid":false,"given":"Marcelo Borges","family":"Cavalcante","sequence":"first","affiliation":[{"name":"Postgraduate Program in Medical Sciences Fortaleza University (UNIFOR  Fortaleza Brazil"},{"name":"CONCEPTUS \u2013 Reproductive Medicine  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel","family":"Sarno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Federal University of Bahia (UFBA  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Barini","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campinas University (UNICAMP  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.10.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.07.1090"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(03)00083-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/211999a0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0474-36"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.1.180"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90413-X"},{"issue":"3","key":"e_1_2_7_9_1","first-page":"247","article-title":"Modifications recommended by FIGO as amended October 14, 1976","volume":"56","author":"WHO: recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths","year":"1977","journal-title":"Acta Obstet Gynecol Scand"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex234"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoy004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.048"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.178.4061.617"},{"issue":"4","key":"e_1_2_7_14_1","first-page":"743","article-title":"Second kidney transplants and presensitization","volume":"4","author":"Opelz G","year":"1972","journal-title":"Transplant Proc"},{"issue":"3","key":"e_1_2_7_15_1","first-page":"315","article-title":"How did your mother not reject you?","volume":"135","author":"Beer AE","year":"1984","journal-title":"Annales d'immunologie"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91723-4"},{"key":"e_1_2_7_17_1","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood. 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