{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:42:41Z","timestamp":1784936561827,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970859"],"award-info":[{"award-number":["31970859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630036"],"award-info":[{"award-number":["81630036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91542116"],"award-info":[{"award-number":["91542116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871170"],"award-info":[{"award-number":["81871170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Problem:<\/jats:bold>\n                    Circadian rhythms are involved not only in the repair and regeneration of the immune system, but may also be associated with regulation of inflammation and immune responses. Rev\u2010erb\u03b1 could constitute a link between immunity and circadian rhythms since it is a transcription factor that regulates circadian rhythms and has functions in multiple physiological and pathological processes. Decidual macrophages (dM\u03c6s) play crucial roles in immune balance at the maternal\u2010fetal interface, and abnormal macrophage polarization is related to adverse pregnancy outcomes, such as infertility, recurrent spontaneous abortion, and preterm labor. However, whether Rev\u2010erb\u03b1 could modulate the polarization of macrophages is unknown.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods of study:<\/jats:bold>\n                    In this study, we analyzed the phenotype of dM\u03c6s and the expression of Rev\u2010erb\u03b1 in dM\u03c6s from normal pregnancies and miscarriages. The effect of Rev\u2010erb\u03b1 on macrophage polarization was evaluated by its knockdown or pharmacological activation. The mechanism by which the Rev\u2010erb\u03b1 agonist SR9009 regulates macrophage polarization was also estimated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A type\u20101 macrophage (M1)\u2010like dominance was observed in dM\u03c6s from human miscarriages, with a decreased expression of Rev\u2010erb\u03b1 compared to that from normal pregnancies. Rev\u2010erb\u03b1 knockdown promoted M1 polarization in macrophages differentiated from the THP1 cell line, whereas pharmacological activation of Rev\u2010erb\u03b1 by SR9009 induced type\u20102 macrophage (M2)\u2010like polarization in dM\u03c6s. Furthermore, we found that SR9009 induced M2 polarization in macrophages differentiated from the U937 cell line via the PI3K\/Akt signaling pathway.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Rev\u2010erb\u03b1 may play an essential role in macrophage polarization. These findings might help elucidate the role of Rev\u2010erb\u03b1 in regulating the differentiation and functions of macrophages and suggest a therapeutic target for pregnancy loss and pregnancy complications.\n                  <\/jats:p>","DOI":"10.1111\/aji.13436","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T05:47:28Z","timestamp":1619934448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Circadian rhythm\u2010associated Rev\u2010erb\u03b1 modulates polarization of decidual macrophage via the PI3K\/Akt signaling pathway"],"prefix":"10.1111","volume":"86","author":[{"given":"Liyuan","family":"Cui","sequence":"first","affiliation":[{"name":"NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research) Hospital of Obstetrics and Gynecology Fudan University Shanghai Medical College Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Jin","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research) Hospital of Obstetrics and Gynecology Fudan University Shanghai Medical College Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research) Hospital of Obstetrics and Gynecology Fudan University Shanghai Medical College Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 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