{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:34Z","timestamp":1787013814015,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>Small for gestational age (SGA) neonates are vulnerable to various long and short\u2010term adverse health consequences. The expression of HLA\u2010G in the placenta is crucial for establishment and maintenance of pregnancy. Its aberrant expression could lead to perturbed immunological interactions in the placenta which could be associated with SGA births. The objective of this study was to assess the difference in the trajectories of soluble HLA\u2010G in maternal sera during pregnancy between women delivering SGA and appropriate for gestational age (AGA) neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of study<\/jats:title>\n                    <jats:p>\n                      Soluble HLA\u2010G was estimated in the maternal sera collected at different time points in pregnancy of North\u2010Indian pregnant females delivering SGA (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a023) or AGA (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a017) neonates using sandwich ELISA. Linear mixed models were built and compared to study the association between sHLA\u2010G levels during pregnancy and SGA births.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant difference was observed in the sHLA\u2010G trajectories during pregnancy in mothers delivering SGA as compared to those delivering AGA (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value\u00a0=\u00a0.5677). A trend towards higher sHLA\u2010G levels at the first trimester of pregnancy (&lt;\u00a014\u00a0weeks of gestation) was observed in mothers delivering SGA neonates (Median\u00a0=\u00a041.71, IQR\u00a0=\u00a021.31\u201371.38) as compared to those delivering AGA neonates (Median\u00a0=\u00a037.58, IQR\u00a0=\u00a019.05\u201373.57).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>During pregnancy, sHLA\u2010G trajectories do not differ significantly between mothers delivering SGA and those delivering AGA neonates. However, sHLA\u2010G trends towards higher levels during early pregnancy in mothers delivering SGA neonates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.13504","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T10:42:13Z","timestamp":1634640133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Longitudinal profile of sHLA\u2010G during pregnancy and its association with small for gestational age births in North Indian pregnant females: A nested case\u2010control study"],"prefix":"10.1111","volume":"87","author":[{"given":"Shilpi","family":"Sehgal","sequence":"first","affiliation":[{"name":"Maternal and Child Health Translational Health Science and Technology Institute  Haryana India"},{"name":"Manipal Academy of Higher Education  Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushrut","family":"Vyawhare","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Translational Health Science and Technology Institute  Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjini","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Translational Health Science and Technology Institute  Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-5155","authenticated-orcid":false,"given":"Pallavi","family":"Kshetrapal","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Translational Health Science and Technology Institute  Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"GARBH\u2010Ini study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/64.4.650"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0039"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2017"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12391"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.21.11520"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi048"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2015.04.001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1997.tb00279.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901173106"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024592901663"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2007.00475.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.05.009"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00742.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.818126"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2011.638955"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5115\/acb.2011.44.4.331"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.07.1977"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy284"},{"key":"e_1_2_12_20_1","unstructured":"GROWTH CHART: Fenton Preterm Growth Charts.2013.https:\/\/www.ucalgary.ca\/fenton\/2013chart"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00198"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2326636"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah032"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.07.070"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(90)90028-T"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12350"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.64"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.122366"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.8.3839"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1306"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.875"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/immu.200390015"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507977112"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425741"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203425"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00109.x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-018-0237-4"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-015-0440-4"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-S3-S2"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106762"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.01.013"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0035"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3552(05)80012-4"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2001.450205.x"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(00)00123-3"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00160"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aji.13504","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:24:42Z","timestamp":1693203882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,11]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/aji.13504"],"URL":"https:\/\/doi.org\/10.1111\/aji.13504","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.170664594.45493237\/v1","asserted-by":"object"}]},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,11]]},"assertion":[{"value":"2021-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13504"}}