{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:32Z","timestamp":1787013812848,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Glucose\/insulin metabolism has been related to recurrent pregnancy loss (RPL) through mechanisms not really clarified. Also, vitamin D deficiency seems to be associated to RPL. The purpose of our study was to evaluate the correlation between glucose\/insulin metabolism parameters and vitamin D levels in women with history of RPL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Observational retrospective study on RPL women. The correlation among vitamin D levels and fasting glucose (FG), fasting insulin (FI), Homeostatic model assessment of insulin resistance (HOMA\u2010IR) index, area under glucose curve (AUC\u2010Glyc) and area under insulin curve (AUC\u2010Ins), was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One\u2010hundred and twenty\u2010seven RPL women were classified into three subgroups (0\u20101\u20102) according to the levels of FI. We found a statistically significant linear Pearson correlation between FI and HOMA\u2010IR (r\u00a0=\u00a0.840;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001). An, inverse, but non\u2010significant correlation both between vitamin D and FI (R\u00a0=\u00a0\u2010.202, ns) and vitamin D levels and AUC\u2010Ins (R\u00a0=\u00a0\u2010.288, ns) was observed. The variables vitamin D, HOMA\u2010IR and AUC\u2010Ins were statistically significant in the considered subgroups (Vitamin D: ANOVA + Bonferroni test: 0\u00a0vs. 1;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001; 0\u00a0vs. 2;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.010; 1\u00a0vs. 2;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.657; HOMA\u2010IR: ANOVA + Bonferroni test: 0\u00a0vs. 1;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.014; 0\u00a0vs. 2;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001; 1\u00a0vs. 2;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001; AUC\u2010Ins: ANOVA + Bonferroni test: 0\u00a0vs. 1;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.010; 0\u00a0vs. 2;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.206; 1\u00a0vs. 2;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.980).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vitamin D might play additional roles in the pathogenesis of RPL, beyond its well known immunomodulatory role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.13505","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T04:56:17Z","timestamp":1634964977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Glucose\/insulin metabolism and vitamin D in women with recurrent pregnancy loss"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-0558","authenticated-orcid":false,"given":"Silvia","family":"D'Ippolito","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna del Bambino e di Sanit\u00e0 Pubblica Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.)  Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Capozzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna del Bambino e di Sanit\u00e0 Pubblica Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.)  Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna del Bambino e di Sanit\u00e0 Pubblica Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.)  Roma Italia"},{"name":"Dipartimento di Scienze della Vita e Sanit\u00e0 Pubblica Universit\u00e0 Cattolica del Sacro Cuore  Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sorge","sequence":"additional","affiliation":[{"name":"Laboratory of Biometry University of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Lello","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna del Bambino e di Sanit\u00e0 Pubblica Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.)  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