{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:39:53Z","timestamp":1783489193324,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>The clinical value of endometrial receptivity array (ERA), endometrial immune profiling, or a combination of both for multiple implantation failure patients is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>One hundred and seventy\u2010two women with a history of at least two or more consecutive implantation failures in IVF\/ICSI treatment were included. According to patients\u2019 willingness, they were divided into four groups, \u2018no treatment\u2019, \u2018Immune Profiling\u2019, \u2018ERA\u2019 and \u2018ERA\u00a0+ Immune Profiling\u2019. Endometrial biopsy was examined by ERA, immune profiling alone, or combination, and intention was adopted accordingly. Pregnancy outcomes were compared, and the association between ERA phases and endometrial immune profiling was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall incidence rate of the displaced window of implantation (WOI) and endometrial immune dysregulations were 84.9% and 75.3%, respectively. Implantation rate was significantly higher in the \u2018ERA\u00a0+ Immune Profiling\u2019 group than the \u2018no treatment\u2019 group (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.007). Clinical pregnancy rate was somewhat improved in the three treatment groups but with a borderline significance (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.071). After controlling for other confounders, \u2018ERA\u00a0+ Immune Profiling\u2019 treatment was associated with a higher pregnancy rate [aOR (95%CI)\u200a\u00a0=\u00a0\u200a3.412 (1.387\u20138.395), <jats:italic>P\u00a0<\/jats:italic>=\u00a0.008]. There was no association between endometrial immune profiling and ERA phases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings highlight the high incidence of displaced WOI and endometrial immune dysregulation in multiple implantation failure patients. The combination of ERA and endometrial immune profiling is more likely to have clinical value than ERA or immune profiling alone. These data suggested the unsubstitutability of ERA and endometrial immune profiling on the treatment outcome for multiple implantation failure patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13513","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T07:07:32Z","timestamp":1636700852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effectiveness comparison between endometrial receptivity array, immune profiling and the combination in treating patients with multiple implantation failure"],"prefix":"10.1111","volume":"87","author":[{"given":"Yan","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Reproductive Immunology Chengdu Xi'nan Gynecology Hospital  Chengdu Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Jun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Reproductive 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