{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:21:17Z","timestamp":1767835277340,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>The COVID\u201019 pandemic has many clinical manifestations. Rapid vaccine development raised concerns and speculations about future fertility outcomes and vaccine safety. We evaluated the effect of Pfizer\u2010BioNTech mRNA SARS\u2010CoV\u20102 vaccine on IVF treatment, oocyte and embryo quality, and pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>This prospective, observational cohort study was conducted in a referral IVF Unit, 3\/2021\u20105\/2021. We aimed to recruit all women undergoing IVF\/ICSI cycles from 3\/1\u20134\/30\/2021, 2\u20108\u00a0weeks after the second vaccination, and to analyze 50\u201360 samples in the 2\u2010month period. Patients were categorized according to serum antibody levels: positive for spike (S), positive for nucleotide (N), or negative for both. On the day of ovum pick\u2010up, follicular fluid and blood samples were analyzed for anti\u2010nucleotide (anti\u2010N) antibodies, and anti\u2010spike (anti\u2010S) antibodies, hormonal profile, C\u2010reactive protein (CRP) and other metabolic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 59 women enrolled, 37 reported being vaccinated and 22 were not. We found 97% correlation between anti\u2010S and anti\u2010N in the blood and the follicular fluid. Follicular fluid was analyzed based on antibody categorization. All IVF treatment parameters in the follicular fluids and serum were comparable, except CRP was significantly elevated among patients with anti\u2010N antibodies (2.29 [1.42\u20136.08] vs. 4.11 [1.62\u20135.75] vs. 1.44 [.36\u20138.33]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Pregnancy outcomes were comparable (44%\u00a0vs. 33%\u00a0vs. 50%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>mRNA SARS\u2010CoV\u20102 vaccine did not appear to affect treatment outcomes or ovarian reserves in the subsequent IVF cycle.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13530","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T11:08:25Z","timestamp":1645960105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Does mRNA SARS\u2010CoV\u20102 vaccine in the follicular fluid impact follicle and oocyte performance in IVF treatments?"],"prefix":"10.1111","volume":"87","author":[{"given":"Rasha","family":"Odeh\u2010Natour","sequence":"first","affiliation":[{"name":"Laniado Hospital, Department of Obstetrics and Gynecology  Netanya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maanit","family":"Shapira","sequence":"additional","affiliation":[{"name":"Laboratory Division Hillel Yaffe Medical Center  Hadera Israel"},{"name":"Ruth and Bruce Rappaport School of Medicine The Technion\u2010Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6496-0834","authenticated-orcid":false,"given":"Daniela","family":"Estrada","sequence":"additional","affiliation":[{"name":"IVF Unit Department of Obstetrics and Gynecology Hillel Yaffe Medical Center  Hadera Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarit","family":"Freimann","sequence":"additional","affiliation":[{"name":"Laboratory Division Hillel Yaffe Medical Center  Hadera Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yana","family":"Tal","sequence":"additional","affiliation":[{"name":"Laboratory Division Hillel 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Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-4202","authenticated-orcid":false,"given":"Einat","family":"Shalom\u2010Paz","sequence":"additional","affiliation":[{"name":"Ruth and Bruce Rappaport School of Medicine The Technion\u2010Institute of Technology  Haifa Israel"},{"name":"IVF Unit Department of Obstetrics and Gynecology Hillel Yaffe Medical Center  Hadera Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249\u2010020\u201001744\u20107"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"107","article-title":"The race for a COVID\u201019 vaccine","volume":"54","author":"Lavigne SE","year":"2020","journal-title":"Can J Dent 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