{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:22:35Z","timestamp":1775308955577,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>FOXP3<\/jats:italic> single nucleotide polymorphisms (SNPs) were recently elucidated to influence the development of preeclampsia (PE), but the results on this issue still remained controversial. Thus, a meta\u2010analysis was implemented to systematically investigate the roles of <jats:italic>FOXP3<\/jats:italic> SNPs in PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible publications were identified by retrieving relevant electronic databases. Meanwhile, the association intensity was estimated by calculating odds ratios (ORs) and 95% confidence intervals (CIs) in various genetic models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally eight investigations involving 3446 subjects were enrolled in the final meta\u2010analysis. The AC and AC + CC genotypes of FOXP3 rs3761548 were related to the susceptibility of PE in over\u2010dominant (OR = 1.19, 95%CI = 1.02\u20101.38, <jats:italic>P<\/jats:italic> = 0.03) and recessive (OR = 0.59, 95% CI: 0.36\u20100.97, <jats:italic>P<\/jats:italic> = 0.04) models. Furthermore, correlation between rs2232365 and PE was observed in recessive model (GG vs. GA + AA) (OR = 0.79, 95%CI: 0.65\u20100.97, <jats:italic>P<\/jats:italic> = 0.03). Moreover, rs2232365 GA and GG + GA genotypes were associated with the severity of PE. However, rs4824747, rs3761547 and rs2280883 polymorphisms had no significant impact on PE susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>FOXP3<\/jats:italic> rs3761548 and rs2232365 SNPs influenced the PE susceptibility and therefore may be potential biomarkers for prediction of PE risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13554","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T11:29:05Z","timestamp":1650454145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations of <i>FOXP3<\/i> gene polymorphisms with susceptibility and severity of preeclampsia: A meta\u2010analysis"],"prefix":"10.1111","volume":"88","author":[{"given":"Yu\u2010Xin","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy The 920th Hospital of Joint Logistics Support Force  Kunming 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