{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T16:00:19Z","timestamp":1775491219989,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1F1A1048362"],"award-info":[{"award-number":["2020R1F1A1048362"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>This study aimed to determine whether various novel plasma mediators of immune regulation associated with inflammation could independently predict the clinical outcome of rescue cerclage in patients with cervical insufficiency (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>A total of 41 singleton pregnant women (17\u201325\u00a0weeks) who underwent rescue cerclage for CI were retrospectively evaluated. Stored plasma samples were assayed for IGFBP\u20101, \u20102, \u20103, IL\u20106, latexin, LBP, lipocalin\u20102, M\u2010CSF, MIP\u20101\u03b1, MMP\u20108, \u20109, pentraxin 3, resistin, S100A8, S100A8\/A9, thrombospondin\u20102, TIMP\u20101, and TNFR2 levels. The primary outcome measures were spontaneous preterm birth (SPTB) at\u00a0&lt;\u00a028 and\u00a0&lt;\u00a034\u00a0weeks after cerclage placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate Firth's logistic regression analysis revealed that high levels of IGFBP\u20103 and S100A8\/A9, and low levels of MIP\u20101\u03b1 were significantly associated with SPTB at\u00a0&lt;\u00a028\u00a0weeks after cerclage placement, whereas only low MIP\u20101\u03b1 levels were significantly associated with SPTB at\u00a0&lt;\u00a034\u00a0weeks, even after adjustment for baseline clinical covariates (e.g., cervical dilatation). For the prediction of SPTB at\u00a0&lt;\u00a028\u00a0weeks, the area under the curves (AUC) of IGFBP\u20103, MIP\u20101\u03b1, and S100A8\/A9 were of .686, .691, and .693, respectively. Similarly, the AUC of MIP\u20101 \u03b1 was of .659 to predict SPTB at\u00a0&lt;\u00a034\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that plasma IGFBP\u20103, MIP\u20101\u03b1, and S100A8\/A9 can represent noninvasive independent biomarkers for identifying women with CI at high risk for SPTB following rescue cerclage. Nonetheless, further in large, multicenter clinical studies should be performed to confirm the clinical value of these biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13557","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T13:14:12Z","timestamp":1651497252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inflammation\u2010related immune proteins in maternal plasma as potential predictive biomarkers for rescue cerclage outcome in women with cervical insufficiency"],"prefix":"10.1111","volume":"88","author":[{"given":"So Yeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Obstetrics and Gynecology University of Ulsan College of Medicine Asan Medical Center  Seoul South 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