{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:31:21Z","timestamp":1768440681960,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T00:00:00Z","timestamp":1653177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>: Pregnancy complications and adverse birth outcomes are in part fueled by the rise in obesity and its associated co\u2010morbidities in western societies. Fetal healthy development and placental function are disturbed by an obese, inflammatory environment associated with cytokines, such as interleukin\u20106, causing inadequate supply of nutrients to the fetus and perinatal programming with severe health consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>: Mice received high fat diet (HFD) before and during gestation to induce obesity. We performed an IL\u20106 receptor antibody (MR16\u20101) treatment in pregnant obese mice at embryonic days E0.5, E7.5 and E14.5 to investigate whether this could ameliorate HFD\u2010induced and obesity\u2010associated placental dysfunction, evaluated by stereology and western blot, and improve offspring outcome at E15.5 in obese dams.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>: We observed fewer fetuses below the 10th percentile and placental vascularization was less aggravated following MR16\u20101 treatment of obese dams, showing slight improvements in labyrinth zone (Lz) vascularization. However, placental dysfunction and fetal growth restriction were still apparent in MR16\u20101 dams compared to lean control dams. Molecular analysis showed significantly elevated IL\u20106 level in placentas of MR16\u20101 treated dams.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>: Treatment with MR16\u20101 blocks IL\u20106 signaling in the placenta, but has only limited effects on preventing HFD\u2010associated placental dysfunction and offspring outcomes in mice, suggesting further mechanisms in the deterioration of placental vascularization and fetal nutrient supply as a consequence of maternal obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13564","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T06:33:21Z","timestamp":1652164401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of high fat diet\u2010induced obese pregnant mice with IL\u20106 receptor antibody does not ameliorate placental function and fetal growth restriction"],"prefix":"10.1111","volume":"88","author":[{"given":"Tobias","family":"Kretschmer","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine University Hospital of Cologne  Cologne Germany"},{"name":"Department Environmental Immunology Helmholtz Centre for Environmental Research \u2010 UFZ  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva\u2010Maria","family":"Turnwald","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Janoschek","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine University Hospital of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Wohlfarth","sequence":"additional","affiliation":[{"name":"Department of 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