{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:11:20Z","timestamp":1787508680667,"version":"build-2736575974"},"reference-count":116,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Polycystic ovarian syndrome (PCOS) is a complicated neuro\u2010endocrinal, reproductive, and metabolic condition. It encompasses patterns such as hyperandrogenism, recurrent cysts triggered by steroidogenic functional aberrations in the ovaries, overweight, chronic inflammation, and more. The underlying cause of this heterogeneous illness is obscure, although it is suspected to be driven by a blend of environmental and hereditary factors. In recent years, the connection between the microbiome and PCOS has been acknowledged and is thought to be involved in the genesis of the syndrome's emergence. Microbiota vary in different pathological features of PCOS, and fundamental pathways linked to their involvement in the commencement of diverse clinical presentations in PCOS open up a new avenue for its management. Prebiotic, probiotic, synbiotic, and fecal\u2010microbiota\u2010transplant, by promoting eubiosis and nullifying the effect caused by the altered microbial profile in PCOS women, can aid in management of diverse phenotypes associated with the syndrome. These microbiota\u2010mediated treatments improve PCOS women's metabolic, inflammatory, and hormonal profiles. However, more studies are needed to elucidate the mechanisms that drive this positive effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.13580","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T09:10:26Z","timestamp":1653210626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Interplay between PCOS and microbiome: The road less travelled"],"prefix":"10.1111","volume":"88","author":[{"given":"Manya","family":"Batra","sequence":"first","affiliation":[{"name":"Centre For Medical Biotechnology Maharshi Dayanand University  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Bhatnager","sequence":"additional","affiliation":[{"name":"Royal Berkshire NHS Foundation Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre For Medical Biotechnology Maharshi Dayanand University  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2697-9168","authenticated-orcid":false,"given":"Pooja","family":"Suneja","sequence":"additional","affiliation":[{"name":"Department of Microbiology Maharshi Dayanand University  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-3502","authenticated-orcid":false,"given":"Amita Suneja","family":"Dang","sequence":"additional","affiliation":[{"name":"Centre For Medical Biotechnology Maharshi Dayanand University  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.87112"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.JHRS_95_18"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/pp9.0000000000000028"},{"key":"e_1_2_11_5_1","first-page":"377","volume-title":"Diagnostic Criteria for PCOS: Towards a More Rational Approach","author":"Zawadeski JK","year":"1992"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","unstructured":"AzzizR CarminaE DewaillyD et\u00a0al.The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report. Vol91;2009.https:\/\/doi.org\/10.1016\/j.fertnstert.2008.06.035","DOI":"10.1016\/j.fertnstert.2008.06.035"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-41"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2478\/enr\u20102018\u20100026"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.57"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz263"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160510"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124234.Metagenomic"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002533"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2020.11.005"},{"key":"e_1_2_11_16_1","first-page":"25","article-title":"Polycystic ovary syndrome","author":"Teede H","year":"2008","journal-title":"Aust Dr."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2020.1781815"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2010.10.002"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.00338.2019"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010021\u201001046\u20105"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153196"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146509"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00449\u2010020\u201002320\u2010w"},{"key":"e_1_2_11_24_1","first-page":"1","article-title":"Evaluation on the characteristics of gut microbiome in polycystic ovary syndrome rats induced by dihydrotestosterone or letrozole","author":"Zheng Y","year":"2021","journal-title":"Res Sq."},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016\u20102586"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005\u20101666"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019\u201000050"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017\u201002153"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.755741"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2019.03.003"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.013"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R116.767434"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw029"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.33552\/OJCAM.2021.06.000628"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.05.016"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100509\u20100"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201019\u20100589"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00324"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004\u20100858"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092753"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.03.003"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coemr.2020.03.004"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12893"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.2147\/btt.s19099"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042048"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02184"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02653"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14198"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.01108"},{"key":"e_1_2_11_50_1","doi-asserted-by":"crossref","unstructured":"PatelN PatelN PalS et\u00a0al.Distinct gut and vaginal microbiota profile in women with recurrent implantation failure and unexplained infertility.medRxiv. Published online 2021:2021.02.09.21251410.","DOI":"10.21203\/rs.3.rs-672281\/v1"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.12.026"},{"key":"e_1_2_11_52_1","article-title":"Characterization of the vaginal microbiota of women with premature ovarian insu ciency","author":"Wen J","year":"2021","journal-title":"Res Sq."},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2014.08.005"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2019.102090"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.662725"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu076"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14421"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2014.11.001"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u2010789X.2012.01053.x"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07540"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05414"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp\u20102019\u20100413"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC\u201019\u20100522"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.167"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808567105"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301403200"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201018259\u20100"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11120869"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00628"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani9060374"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201014\u20100589"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06\u20101491.P.D.C"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.165886"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117936"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106793\u20106\u20102"},{"issue":"1","key":"e_1_2_11_76_1","first-page":"1","article-title":"Insulin resistance in obese and lean women with polycystic ovarian syndrome","volume":"8","author":"Jayashree S","year":"2018","journal-title":"Int J Reprod Contraception, Obstet Gynecol."},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424\u2010017\u20101955\u20105"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2018.09.002"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010021\u201000799\u20109"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518189113"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.634981"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.34171\/mjiri.34.5"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab118"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.013"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9553"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14101"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.17179\/excli2020\u20103239"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902\u2010019\u20100486\u20109"},{"key":"e_1_2_11_89_1","article-title":"Increased trimethylamine N\u2010oxide contributes to metabolic dysfunction in a rat model of pcos and decreases mitochondrial function","author":"Jiayu H","year":"2020","journal-title":"Res Sq."},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182549092"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.4103\/2008\u20107802.153866"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2017.1283446"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.06.029"},{"issue":"1","key":"e_1_2_11_94_1","first-page":"1","article-title":"Effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomized, double\u2010blind, placebo\u2010controlled trial","volume":"21","author":"Karamali M","year":"2018","journal-title":"Arch Iran Med."},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.12.047"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602\u2010018\u20109493\u20109"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010019\u201002033\u20101"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010019\u20100480\u2010x"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010018\u20100457\u20101"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-018-1648-7"},{"issue":"11","key":"e_1_2_11_101_1","first-page":"201","article-title":"Effect of prebiotic on anthropometric indices in women with polycystic ovarian syndrome: a triple\u2010blind, randomized, controlled clinical trial","volume":"20","author":"Gholizadeh Shamasbi S","year":"2018","journal-title":"Iran Red Crescent Med J."},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-005-0552-0"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-018-0248-0"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-020-0524-5"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.22074\/IJFS.2021.6186"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01244-4"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010313017"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.031"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1360\/N972018\u201000587"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517003920"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017\u201002799"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.01.027"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfnr.2021.03.003"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168390"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa848"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13417"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa600"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aji.13580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:56:10Z","timestamp":1692852970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,29]]},"references-count":116,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/aji.13580"],"URL":"https:\/\/doi.org\/10.1111\/aji.13580","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,29]]},"assertion":[{"value":"2022-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13580"}}