{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:23Z","timestamp":1753878383898,"version":"3.41.2"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The SARS\u2010CoV\u20102 virus, which causes COVID\u201019, has spread quickly worldwide, causing millions of cases and thousands of deaths. Some risk factors in the general population are related to the development of severe COVID\u201019 or death, but in pregnant women and neonates, the information is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the epidemiological and clinical characteristics of pregnant women and neonates diagnosed with COVID\u201019 by RT\u2013PCR and serological tests, and analyze the relationship between the influenza vaccination and COVID\u201019 symptoms in infected pregnant women in Sinaloa state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected samples from 116 pregnant women and 84 neonates from the Women\u00b4s Hospital of Sinaloa. They were diagnosed with COVID\u201019 by RT\u2013PCR and serological tests (IgG), and sociodemographic, clinical and laboratory parameters were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 11.2% (13\/116) of the pregnant women were RT\u2013PCR+, 25% (29\/116) were IgG+ and 4.3% (5\/116) were positive for both tests. Symptoms such as rhinorrhea (<jats:italic>P\u00a0=\u00a0<\/jats:italic>.04), cough (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.02) and polypnea (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.04) in pregnant women were related to COVID\u201019, also leukocyte index was higher in pregnant women with COVID\u201019 (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.03), but the associations were lost after the Bonferroni correction. No laboratory parameters or underlying diseases were associated with COVID\u201019, and most infected pregnant women had mild cases. We found an association between the influenza vaccine and less common COVID\u201019 symptoms in pregnant women\u00a0who were\u00a0infected (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.01). A total of 7.2% (6\/84) of neonates were RT\u2013PCR+, 35.7% (30\/84) were IgG+, and there were no symptoms or underlying diseases associated with neonates who were infected. In conclusion, this work demonstrated that some symptoms were related to COVID\u201019, most pregnant women and neonates had mild cases, and the influenza vaccine could decrease the severity of COVID\u201019 cases in pregnant women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13583","type":"journal-article","created":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T08:34:28Z","timestamp":1654418068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiological and clinical characteristics of pregnant women and neonates with COVID\u201019 in Northwest Mexico"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-3383","authenticated-orcid":false,"given":"Nidia","family":"Leon\u2010Sicairos","sequence":"first","affiliation":[{"name":"CIASaP School of Medicine Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"},{"name":"Pediatric Hospital of Sinaloa  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-0766","authenticated-orcid":false,"given":"Uriel A.","family":"Angulo\u2010Zamudio","sequence":"additional","affiliation":[{"name":"CIASaP School of Medicine Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireya","family":"Pacheco\u2010Avila","sequence":"additional","affiliation":[{"name":"The Women's Hospital, Secretariat of Health  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Medina\u2010Ramirez","sequence":"additional","affiliation":[{"name":"The Women's Hospital, Secretariat of Health  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0095-6892","authenticated-orcid":false,"given":"Jorge","family":"Velazquez\u2010Roman","sequence":"additional","affiliation":[{"name":"CIASaP School of Medicine Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7573-2017","authenticated-orcid":false,"given":"Jorge","family":"Angulo\u2010Rocha","sequence":"additional","affiliation":[{"name":"The Women's Hospital, Secretariat of Health  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-6221","authenticated-orcid":false,"given":"Francisco A.","family":"Mart\u00ednez\u2010Villa","sequence":"additional","affiliation":[{"name":"CIASaP School of Medicine Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-8019","authenticated-orcid":false,"given":"Hector","family":"Flores\u2010Villase\u00f1or","sequence":"additional","affiliation":[{"name":"CIASaP School of Medicine Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"},{"name":"The Sinaloa State Public Health Laboratory Secretariat of Health  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9555-262X","authenticated-orcid":false,"given":"Jesus J.","family":"Martinez\u2010Garcia","sequence":"additional","affiliation":[{"name":"CIASaP School of Medicine Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"},{"name":"Pediatric Hospital of Sinaloa  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Sanchez\u2010Cuen","sequence":"additional","affiliation":[{"name":"CIASaP School of Medicine Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Garzon\u2010Lopez","sequence":"additional","affiliation":[{"name":"The Women's Hospital, Secretariat of Health  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Guel\u2010Gomez","sequence":"additional","affiliation":[{"name":"The Women's Hospital, Secretariat of Health  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector Melesio","family":"Cuen\u2010Diaz","sequence":"additional","affiliation":[{"name":"FCA, Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Francisco","family":"Barajas\u2010Olivas","sequence":"additional","affiliation":[{"name":"The Women's Hospital, Secretariat of Health  Culiacan Sinaloa Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Campos\u2010Romero","sequence":"additional","affiliation":[{"name":"Salud Digna A.C.  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