{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:31:27Z","timestamp":1790163087966,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T00:00:00Z","timestamp":1657411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>We aimed to assess the predictive potential of 12 plasma biomarkers to predict acute histologic chorioamnionitis (HCA) in women with preterm premature rupture of membranes (PPROM) and to develop multi\u2010biomarker panels based on these biomarkers in combination with widely used conventional laboratory markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>This was a retrospective cohort study involving 81 singleton pregnant women (24\u201334\u00a0weeks of gestation) who delivered within 96 h of blood sampling. White blood cell (WBC) count, differential counts, and C\u2010reactive protein (CRP) levels were measured at admission. The levels of DKK\u20103, Fas, haptoglobin, IGFBP\u20102, kallistatin, MIP\u20101\u03b1, MMP\u20102, MMP\u20108, pentraxin 3, progranulin, E\u2010selectin, and P\u2010selectin were evaluated by ELISA using stored plasma samples. The primary outcome measure was acute HCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analyses showed that low plasma E\u2010selectin and kallistatin levels were independently associated with HCA occurrence after adjusting for gestational age. Using a stepwise regression analysis, a multi\u2010biomarker panel comprising plasma E\u2010selectin, serum CRP, and WBC was developed, which provided a good prediction of acute HCA in women with PPROM (area under the curve [AUC], 0.899), with a significantly higher AUC than that of any single variable included in the panel (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). The plasma levels of DKK\u20103, Fas, haptoglobin, IGFBP\u20102, MIP\u20101\u03b1, MMP\u20102, MMP\u20108, pentraxin 3, and P\u2010selectin were not significantly associated with HCA occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study identified E\u2010selectin and kallistatin as potential plasma biomarkers associated with acute HCA in women with PPROM. Their combined analysis with serum CRP and WBC counts significantly improved acute HCA diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13584","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T01:40:59Z","timestamp":1656639659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Plasma E\u2010selectin and kallistatin as predictive markers of histologic chorioamnionitis in women with preterm premature rupture of membranes"],"prefix":"10.1111","volume":"88","author":[{"given":"Iseop","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong\u2010No","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunwook","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-9686","authenticated-orcid":false,"given":"Kyo Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2017.07.012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13886"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.958463"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719119828043"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.13.2.102.109"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.040"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12360"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.666592"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174657"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043677"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-0997(1997)5:4<273::AID-IDOG3>3.0.CO;2-Y"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.04.019"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200311"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.04.014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488080"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2012.0134"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(03)00071-6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01878"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07861"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.961009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.10.018"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13371"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.8.1226"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175455"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.219"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2021.36.e279"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244720"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90028-4"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/145.1.1"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.01.040"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199305000-00004"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6661(199709\/10)6:5<254::AID-MFM2>3.0.CO;2-F"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085716"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.699116"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8073476"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00166.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000148713.48218.86"},{"issue":"2","key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.4049\/jimmunol.150.2.644","article-title":"Soluble E\u2010selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock","volume":"150","author":"Newman W","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05309.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.08.021"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1427058"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1177271916684823"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i43.6745"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.11.3820"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(96)90152-3"},{"issue":"1","key":"e_1_2_9_49_1","first-page":"174","article-title":"Expression of kallikrein\u2010binding protein and alpha 1\u2010antitrypsin genes in response to sex hormones, growth, inflammation and hypertension","volume":"38","author":"Chao J","year":"1992","journal-title":"Agents Actions Suppl"},{"issue":"12","key":"e_1_2_9_50_1","first-page":"705","article-title":"Biochemistry, regulation and potential function of kallistatin","volume":"376","author":"Chao J","year":"1995","journal-title":"Biol Chem Hoppe Seyler"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.02.003"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12507"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(03)00054-7"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178387"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0919-4"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.108514"},{"issue":"11","key":"e_1_2_9_57_1","first-page":"6390","article-title":"Kallistatin alleviates heart failure in rats by inhibiting myocardial inflammation and apoptosis via regulating sirt1","volume":"24","author":"Xie J","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.11.028"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01385.x"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150217"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12323"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-04101-z"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2016.57.2.461"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12073"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.765404"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173312"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198809000-00006"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004377"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00972"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31002-4"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1854"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.11.002"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0268291"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.947574"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.6.674"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200112126"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.11.032"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-017-2885-1"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0396-0"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aji.13584","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T11:04:15Z","timestamp":1692615855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,10]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/aji.13584"],"URL":"https:\/\/doi.org\/10.1111\/aji.13584","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,10]]},"assertion":[{"value":"2022-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13584"}}