{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:03:29Z","timestamp":1785769409353,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Progress in understanding the underlying mechanism responsible for the syndrome pre\u2010eclampsia should reconfigure antenatal clinical care and minimize human and financial costs, yet at present there is no accurate theory that permits development of reliable predictive tests and prophylactic intervention to mitigate disease. To contribute to this ongoing effort, we aimed to assess various circulating markers pertaining to different theories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Serum samples from thirty\u2010four women with established early onset preeclampsia (ePE) were assessed in terms of oxidative stress (malondialdehyde\u2010 MDA), angiogenic status (PlGF &amp; sFLT\u20101), complement system (The alternative pathway\u2010 AP<jats:sub>50<\/jats:sub> and complement factor H\u2010 CFH) and circulating inflammatory markers (Interleukin 6\u2010 IL\u20106 &amp; Procalcitonin\u2010 PCT). Control groups of gestational age matched patients included 20 gestational hypertensive (GH) and six normotensive pregnant women (NPW).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our work shows that PlGF is the only serum marker who does exhibit a continued decrease from NPW to GH to ePE (r<jats:sub>pearson<\/jats:sub> = \u2010.428, <jats:italic>p<\/jats:italic> = .002). The ePE group had a profound impairment in circulating PlGF (66.93 \u00b1 20.62 pg\/ml) compared to GH (142.67 \u00b1 39.79 pg\/ml; <jats:italic>p<\/jats:italic> = .069) and NPW (636.83 \u00b1 392.66 pg\/ml; <jats:italic>p<\/jats:italic> = .002). Then, PlGF &gt;71.29 pg\/ml pg\/ml is the cut\u2010off that has the highest negative predictive value enabling exclusion of ePE (Sp 78%, Se 70%, <jats:italic>p<\/jats:italic> = .000). No such interesting results could be obtained with the other markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data confirm that the angiogenic factor PlGF may be highly relevant in biological mechanisms underlying the development of ePE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13587","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T07:08:20Z","timestamp":1656572900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The evaluation of some serum immunochemical markers in early onset pre\u2010eclamptic women from Algeria"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-7614","authenticated-orcid":false,"given":"Kheir eddine","family":"Kerboua","sequence":"first","affiliation":[{"name":"Laboratory of Desert Medicine Faculty of Medicine University of Kasdi Merbah  Ouargla Algeria"},{"name":"Laboratory of Immunology Regional Military University Hospital of Oran  Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"Laasla","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry Regional Military University Hospital of Oran  Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591576605900503"},{"key":"e_1_2_7_3_1","article-title":"Complement activation and regulation in preeclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome","author":"Burwick RM","year":"2020","journal-title":"Am J Obstetr Gynecol"},{"key":"e_1_2_7_4_1","article-title":"Clinical tools and biomarkers to predict preeclampsia","volume":"75","author":"MacDonald TM","year":"2022","journal-title":"The Lancet. EBioMedicine"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1111726"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2006.04.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02473.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/263109"},{"issue":"3","key":"e_1_2_7_9_1","article-title":"The alternative complement pathway activity may depend on plasma malondialdehyde level in systemic lupus erythematosus patients: preliminary results","volume":"38","author":"Kerboua KE","year":"2016","journal-title":"Egypt Rheumatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.01.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2021.12.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003215"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.10.005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01420"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fc3afa"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.03.021"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13033"},{"issue":"5","key":"e_1_2_7_18_1","article-title":"Oxidative stress markers in hypertensive states of pregnancy: preterm and term disease","author":"Kurlak LO","year":"2014","journal-title":"Front Physiol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009400"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2022.01.017"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.09.021"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.07.039"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01330.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13311"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12823"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aji.13587","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T11:04:41Z","timestamp":1692615881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/aji.13587"],"URL":"https:\/\/doi.org\/10.1111\/aji.13587","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,7]]},"assertion":[{"value":"2022-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13587"}}