{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:29:19Z","timestamp":1790296159528,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773331"],"award-info":[{"award-number":["81773331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073450"],"award-info":[{"award-number":["82073450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFC0901500"],"award-info":[{"award-number":["2016YFC0901500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Idiopathic inflammatory myopathy (IIM) in pregnancy is uncommon but may result in complications for both mother and the fetus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In this systematic review, we summarized the current literature investigating outcomes of pregnancy related to the dermatomyositis\/polymyositis (DM\/PM) process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Content<\/jats:title><jats:p>We searched PubMed, Embase, Cochrane Library, and Web of Science databases and included 61 studies reporting the disease course, pregnancy outcomes, and management of both pregnancy and DM\/PM in the final analysis.The specific information of 221 pregnancies was extracted and these pregnancies were divided into three distinct forms: pregnancies after disease onset (<jats:italic>n<\/jats:italic>\u00a0=\u00a0159), pregnancies with new disease onset (<jats:italic>n<\/jats:italic>\u00a0=\u00a037), and pregnancies followed by postpartum onset (<jats:italic>n<\/jats:italic>\u00a0=\u00a025). In most cases, DM\/PM disease activity remained stable or improved throughout pregnancy (80.2%) and the postpartum period (83.9%). Active DM\/PM during pregnancy significantly increased the risk of stillbirth or neonatal death (12%\u00a0vs. 1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) and preterm birth (34.7%\u00a0vs. 11%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The rates of other poor outcomes (total fetal loss, low birth weight, and intrauterine growth retardation) were also increased in pregnancies with active disease. Mainstay treatments for active DM\/PM during pregnancy are glucocorticoids and intravenous immunoglobins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications<\/jats:title><jats:p>The present results underline the importance of good control of myopathy in optimizing the pregnancy outcomes of women with DM\/PM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13603","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T18:39:22Z","timestamp":1658515162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Pregnancy in adult\u2010onset dermatomyositis\/polymyositis: A systematic review"],"prefix":"10.1111","volume":"88","author":[{"given":"Keyun","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1977"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.783416"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(02)00021-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.11.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez666"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39311"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90073-C"},{"issue":"3","key":"e_1_2_8_10_1","first-page":"417","article-title":"Dermatomyositis associated with pregnancy","volume":"9","author":"Glickman FS","year":"1958","journal-title":"U S Armed Forces Med J"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.3.406"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg318"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex070"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15970"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140438"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.159"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2016.24.192.9690"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000253244.45837.7c"},{"issue":"1","key":"e_1_2_8_19_1","first-page":"17","article-title":"Autoimmune inflammatory myopathy in pregnancy","volume":"10","author":"Chopra S","year":"2008","journal-title":"Medscape J Med"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.625495"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X18808646"},{"key":"e_1_2_8_22_1","first-page":"4914631","article-title":"Polymyositis\u2010dermatomyositis and interstitial lung disease in pregnant woman successfully treated with cyclosporine and tapered steroid therapy","volume":"2019","author":"Mayu S","year":"2019","journal-title":"Case Rep Rheumatol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2177\/jsci.33.142"},{"key":"e_1_2_8_24_1","first-page":"4527597","article-title":"Use of high\u2010flow nasal cannula oxygen therapy in a pregnant woman with dermatomyositis\u2010related interstitial pneumonia","volume":"2017","author":"Shoji T","year":"2017","journal-title":"Case Rep Crit Care"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000996"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.841785"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.181460"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2007.05.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03165.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270307"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-04851-1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez527"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu222cr"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-017-1368-2"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1166-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20913"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken046"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2016.23.117.9198"},{"issue":"2","key":"e_1_2_8_39_1","article-title":"Pregnancy outcomes in dermatomyositis and polymyositis patients","volume":"55","author":"Missumi LS","year":"2015","journal-title":"Rev Bras Reumatol"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5359.15087"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev404"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aji.13603","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:41:31Z","timestamp":1692682891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/aji.13603"],"URL":"https:\/\/doi.org\/10.1111\/aji.13603","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,23]]},"assertion":[{"value":"2022-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13603"}}