{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:26:07Z","timestamp":1772601967758,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Various cytokines released by white blood cells like lymphocytes are linked to the immune system during pregnancy. The polymorphism of the TNFSF11 (rs2200287 and rs2148072) gene is related to the preeclampsia of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This study was a prospective study involving 304 pregnant women with preeclampsia (<jats:italic>n<\/jats:italic>\u00a0=\u00a0152) and controls (non\u2010preeclamptic pregnant women) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0152). To investigate the rs2200287 and rs2148072 SNP's of TNFSF11 gene polymorphism by using the PCR\u2013RFLP techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significantly different genotype distribution of TNFSF11 (rs2200287 and rs2148072) polymorphisms were observed between the two groups, with the G allele of variant rs2200287 was highly significant in the preeclamptic group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.000; .5814; OR\u00a0=\u00a0.5814; 95% CI\u00a0=\u00a0.4211\u2013.8012). And the C allele of variant rs2148072 was also highly significant in the preeclamptic group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.000; OR\u00a0=\u00a0.5076; 95% CI, .362\u2013.71) in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The outcomes of the present study indicate that there was an association in TNFSF 11 (rs2200287 and rs2148072) gene polymorphism with preeclampsia compared to non\u2010preeclampsia women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13604","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T12:10:40Z","timestamp":1658578240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of TNFSF11 rs2200287 and TNFSF11 rs2148072 gene polymorphisms in preeclampsia"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7087-7786","authenticated-orcid":false,"given":"Nagarjuna","family":"Sivaraj","sequence":"first","affiliation":[{"name":"Department of Biochemistry&amp; Bioinformatics GITAM Deemed to be University  Visakhapatnam Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bunga Papa","family":"Kusuma","sequence":"additional","affiliation":[{"name":"Central Research Laboratory Great Eastern Medical School &amp; Hospital  Ragolu Srikakulam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L V Simhachalam","family":"Kutikuppala","sequence":"additional","affiliation":[{"name":"Dr. N.T.R. University of Health Sciences  Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K Vijaya","family":"Rachel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry&amp; Bioinformatics GITAM Deemed to be university  Visakhapatnam Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya Sirisha","family":"Balaga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Great Eastern Medical School &amp; Hospital  Ragolu Srikakulam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samhitha","family":"Gundakaram","sequence":"additional","affiliation":[{"name":"Department of Medicine Great Eastern Medical School &amp; Hospital  Ragolu Srikakulam India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"894","article-title":"Levels of 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