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RSA is defined as at least three unexplained abortions (without prior live birth) occurring before the 20th week of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present review attempts to discuss immunologic deviations in mouse models of RSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Content<\/jats:title><jats:p>The mating of DBA\/2J males with CBA\/J female mice has provided specialists with a homologous model of RSA. Much of the research using the CBA\/J \u00d7 DBA\/2J mouse model has shown immune system alteration results in rejection. The link between RSA and the immune system suggests new approaches to prevent RSA from an immunological perspective. Rejection in this model is linked with the changed immune system during pregnancy, including change in Th1\/Th2 ratio and defects in T and NK cells function, and so forth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications<\/jats:title><jats:p>The use of animal models prone to RSA can help a lot to solve the remained mysteries. This study reviews the existing knowledge of immune system roles in the RSA mouse models.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13631","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T05:53:43Z","timestamp":1664862823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Immunologic deviations in recurrent spontaneous abortion mouse model"],"prefix":"10.1111","volume":"88","author":[{"given":"Hossein","family":"Ansariniya","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Reproductive Immunology Research Center Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fateme","family":"Zare","sequence":"additional","affiliation":[{"name":"Reproductive Immunology Research Center Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariman","family":"Mosaffa","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Idali","sequence":"additional","affiliation":[{"name":"Reproductive Immunology Research Center Avicenna Research Institute, ACECR  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Shabani","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Hadinedoushan","sequence":"additional","affiliation":[{"name":"Reproductive Immunology Research Center Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"38","volume-title":"Glob Libr Women's Med","author":"Schust D","year":"2008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0553-x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1995.tb01142.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(80)90404-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22893"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/smim.2000.0317"},{"issue":"8","key":"e_1_2_6_8_1","first-page":"1261","article-title":"Mesenchymal stem cell therapy prevents abortion in CBA\/J\u00d7 DBA\/2 mating","volume":"25","author":"Sadighi\u2010Moghaddam B","year":"2018","journal-title":"J\u00a0Cell Physiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00847.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02317"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12595"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074300"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01127-4"},{"issue":"9","key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.4049\/jimmunol.151.9.4562","article-title":"Synthesis of T helper 2\u2010type cytokines at the maternal\u2010fetal interface","volume":"151","author":"Lin H","year":"1993","journal-title":"J\u00a0Immunol"},{"issue":"2","key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4049\/jimmunol.156.2.653","article-title":"T helper 1 response against Leishmania major in pregnant C57BL\/6 mice increases implantation failure and fetal resorptions. 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