{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T23:12:25Z","timestamp":1775689945183,"version":"3.50.1"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1F1A1048362"],"award-info":[{"award-number":["2020R1F1A1048362"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>To determine whether altered levels of 13 plasma biomarkers, alone or in combination, could be independently associated with histologic chorioamnionitis (HCA) and microbial\u2010associated HCA (defined as the presence of HCA along with microbial invasion) in women with preterm labor (PTL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods of Study<\/jats:title><jats:p>This was a retrospective cohort study involving 77 singleton pregnant women with PTL (23\u201334 gestational weeks) who delivered within 96\u00a0h of plasma and amniotic fluid (AF) sampling. DKK\u20103, E\u2010selectin, Fas, haptoglobin, IGFBP\u20101, kallistatin, MMP\u20102, MMP\u20108, pentraxin 3, progranulin, P\u2010selectin, SAA4, and TGFBI levels were assayed in plasma samples by ELISA. AF obtained via amniocentesis was used for microorganism identification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple logistic regression analyses revealed significant associations between low plasma IGFBP\u20101 levels and acute HCA, and between low plasma Fas and kallistatin levels, and elevated plasma P\u2010selectin levels and microbial\u2010associated HCA (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), after adjusting for gestational age. Using a stepwise regression procedure, a multi\u2010biomarker panel for microbial\u2010associated HCA was developed, which included plasma MMP\u20102, kallistatin, and P\u2010selectin levels (area under the curve [AUC], .867). The AUC for this three\u2010marker panel was significantly or borderline significantly greater than that of any single variable included in the panel. However, a predictive model for acute HCA could not be developed because only one variable (MMP\u20102) was selected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings demonstrate that IGFBP\u20101, Fas, kallistatin, and P\u2010selectin are associated with acute HCA and microbial\u2010associated HCA in women with PTL. Their combined use can significantly improve the diagnostic ability for the detection of microbial\u2010associated HCA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13645","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T21:58:00Z","timestamp":1667339880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Plasma IGFBP\u20101, Fas, kallistatin, and P\u2010selectin as predictive biomarkers of histologic chorioamnionitis and associated intra\u2010amniotic infection in women with preterm labor"],"prefix":"10.1111","volume":"89","author":[{"given":"Kyong\u2010No","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iseop","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Mi","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunji","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyo Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0862-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1668S"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.040"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12296"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.11.032"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13517"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.11.1417"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004377"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e90046"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90028-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173312"},{"issue":"6","key":"e_1_2_9_14_1","first-page":"941","article-title":"The relationship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioamnion infection","volume":"81","author":"Hillier SL","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610600604432"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200210"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.07.080"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31816102aa"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05061-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701227877"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200005000-00008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201600028"},{"key":"e_1_2_9_23_1","unstructured":"GulharR AshrafMA JialalI Physiology acute phase reactants. 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