{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:45:10Z","timestamp":1791567910338,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071617"],"award-info":[{"award-number":["82071617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the reproductive outcomes by comparing two kinds of antibiotic schemes for chronic endometritis (CE) in infertile women's fresh embryo transfer (FET) cycles and identify subgroups of patients with CE who need long\u2010term antibiotics treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University\u2010based reproductive medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient(s)<\/jats:title><jats:p>A total of 492 women with CD138\u2010positive plasmacytes per 10 high\u2010power fields (CD138+\/10HPF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention(s)<\/jats:title><jats:p>Hysteroscopy was performed and endometrial biopsy samples were collected in the proliferative phase. Long\u2010term or short\u2010term antibiotics were administrated. After antibiotics treatment, patients underwent in vitro fertilization (IVF)\/ intracytoplasmic sperm injection (ICSI) and received ET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure(s)<\/jats:title><jats:p>Ongoing pregnancy rate, clinical pregnancy rate, clinical miscarriage rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result (s)<\/jats:title><jats:p>There were no significant differences in pregnancy outcomes between patients with CD138+\/10HPF 1\u20134 (low\u2010grade CE) who received long\u2010term antibiotic therapy and short\u2010term antibiotics groups. Among women with CD138+\/10HPF \u22655 (high\u2010grade CE), live birth rate (48.4%\u00a0vs. 14.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), clinical pregnancy rate (66.7%\u00a0vs. 35.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002) and ongoing pregnancy rate (59.1%\u00a0vs. 20.6%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) in the long\u2010term arm were significantly higher than that in the short\u2010term arm. The clinical miscarriage rate (21.0%\u00a0vs. 58.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.013) was statistically lower in the long\u2010term antibiotics group, but no statistical differences were found between the two groups in preterm delivery rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term antibiotics treatment was a sensible choice to improve pregnancy outcomes in women with CD138+\/10HPF \u22655 (high\u2010grade CE). The pregnancy outcomes of women with low\u2010grade CE only defined by histological diagnosis were not greatly improved after antibiotic therapy. Therefore, we recommended the proper diagnosis criteria were CD138+\/10HPF \u22655 pathologically.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13669","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T11:53:45Z","timestamp":1671191625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of different antibiotic therapies on the reproductive outcomes of fresh embryo transfer for chronic endometritis: A retrospective cohort study"],"prefix":"10.1111","volume":"89","author":[{"given":"Jingjing","family":"Liu","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheling","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine The Third Affiliated Hospital of Zheng Zhou University  Zhengzhou 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