{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:18:46Z","timestamp":1781108326923,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012467","name":"Distinguished Professor of Liaoning Province","doi-asserted-by":"publisher","award":["2017"],"award-info":[{"award-number":["2017"]}],"id":[{"id":"10.13039\/501100012467","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>To illustrate the clinical features, treatment strategy, and pregnancy outcome of patients with obstetric antiphospholipid syndrome (OAPS), non\u2010criteria obstetric antiphospholipid syndrome (NC\u2010OAPS)<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>A single\u2010center nested case\u2010control study was designed. Patients with a diagnosis of OAPS and NC\u2010OAPS were enrolled. The medical history, coagulation status, and antibody profile data were collected. Patients were given standard anticoagulation therapy with or without glucocorticoids (GC) and\/or hydroxychloroquine (HCQ) during pregnancy and were observed for their pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 47 patients with OAPS and 120 patients with NC\u2010OAPS were finally included, of whom 55 patients met the clinical criteria (subgroup C) and 65 met the laboratory criteria (subgroup L). Pregnancy morbidity showed significant differences: gravida, pregnancy loss in OAPS versus NC\u2010OAPS. The coagulation function was not significantly different between OAPS and NC\u2010OAPS groups, while TT and FIB were significantly higher in the subgroup C. Thromboelastography (TEG) results showed a significantly lower ANGEL in the NC\u2010OAPS group, a higher ANGEL and lower EPL, LY30 in the subgroup L. No differences between groups were observed in treatment strategy. The pregnancy outcomes were not significantly different between NC\u2010OAPS and OAPS groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical and laboratory differences were found between OAPS and NC\u2010OAPS groups in this study. Patients in different subgroups of NC\u2010OAPS could be identified with different clinical phenotypes. A relatively hypercoagulable status existed in the OAPS group compared to NC\u2010OAPS, and also in the subgroup L.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13684","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T07:25:18Z","timestamp":1675927518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical phenotype, treatment strategy and pregnancy outcome of non\u2010criteria obstetric antiphospholipid syndrome"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-2199","authenticated-orcid":false,"given":"Jiapo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University  Shenyang China"},{"name":"Key Laboratory of Reproductive and Genetic Medicine National Health Commission  Shenyang China"},{"name":"Key Laboratory of Maternal\u2010Fetal Medicine of 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