{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:32Z","timestamp":1787013812324,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>Previous studies document an association between mode of delivery (MOD) and allergic conditions in children. Immunoglobulin (Ig) concentrations at birth may play a role. The goal of this study is to assess the impact of MOD on Ig concentrations at delivery from newborn dried blood spots (DBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of study<\/jats:title>\n                    <jats:p>\n                      The Upstate KIDS Study (2008\u20132010) is a prospective cohort of mother\u2010child pairs recruited from New York State, excluding New York City. Ig subtypes IgA, IgE, IgG\n                      <jats:sub>1<\/jats:sub>\n                      , IgG\n                      <jats:sub>2<\/jats:sub>\n                      , IgG\n                      <jats:sub>3<\/jats:sub>\n                      , IgG\n                      <jats:sub>4<\/jats:sub>\n                      , and IgM were measured in residual NDBS from the Newborn Screening Program (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a03274 infants). MOD was categorized as vaginal delivery (VD), emergency cesarean delivery (ECD) or planned cesarean delivery (PCD). Associations between MOD and Ig levels were assessed using ANOVA and multiple regression, with models adjusted for gestational age, birth weight, maternal race, plurality, and smoking status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IgA, and the IgG subtypes IgG\n                      <jats:sub>3<\/jats:sub>\n                      and IgG\n                      <jats:sub>4<\/jats:sub>\n                      were found to be significantly lower in PCD neonates relative to VD neonates in adjusted regression models: 3.57\u00a0mg\/ml, (95% CI: 3.51, 3.63) compared to 3.64\u00a0mg\/ml (95% CI: 3.59, 3.69); 8.95\u00a0ng\/ml (95% CI: 8.88,9.03) compared to 9.03\u00a0ng\/ml (95% CI: 8.98, 9.08) and 8.05\u00a0ng\/ml (95% CI: 7.91, 8.20) compared to 8.22\u00a0ng\/ml (95% CI: 7.91,8.20), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MOD may thus be related to neonatal immune profile. Results were found to be robust to sensitivity testing based on maternal complications and indication for CD.<\/jats:p>\n                    <jats:p>Clinical implications are unclear given the small levels of association found in newborns, but the result suggests greater susceptibility to infection, and further study is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.13688","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T23:14:44Z","timestamp":1676416484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects on neonatal immunoglobulin concentrations by infant mode of delivery in the upstate KIDS study (2008\u20132010)"],"prefix":"10.1111","volume":"89","author":[{"given":"Temilayo E.","family":"Adeyeye","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health State University of New York  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health State University of New York  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwina","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Population Health Research Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Mendola","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health, School of Public Health and Health Professions State University of New York  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health State University of New York  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health State University of New York  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health State University of New York  Albany New York USA"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health State University of New York  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.2011.00195.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy257"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0596"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-12-179"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.08.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13014-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2010.09.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174412000712"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.03.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/542091"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184748"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(67)90356-0"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(71)90837-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-012-0247-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.603050"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.12.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12121"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.02.033"},{"key":"e_1_2_9_20_1","unstructured":"New York State Department of Health. 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