{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T21:54:32Z","timestamp":1783288472409,"version":"3.54.6"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Soluble Fms\u2010like tyrosine kinase\u20101 (sFLT\u20101) and placental growth factor (PlGF) were previously reported to play a key role in the pathogenesis of preeclampsia (PE). We tested the link between altered PlGF and sFLT\u20101 levels, and their ratio (sFlt\u20101\/PlGF) with PE and PE\u2010associated featured in Tunisian PE cases and age\u2010 and BMI\u2010matched normotensive women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>Peripheral blood specimens from 88 women with PE, and 60 control women were tested for PlGF and sFLT by commercially available ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant increases in sFlt\u20101 levels and in the sFlt\u20101\/PlGF ratio, more than changes in PlGF levels were noted in PE subjects when compared to control women. Elevation in sFlt\u20101 and sFlt\u20101\/PlGF ratio was observed at different percentile values in PE cases. The receiver operating characteristic (ROC) area under the curve (AUC) for sFlt\u20101, PlGF, and sFlt\u20101\/PlGF ratio were 0.869\u00a0\u00b1\u00a00.031, 0.463\u00a0\u00b1\u00a00.048, and 0.759\u00a0\u00b1\u00a00.039, respectively. A systematic shift in sFlt\u20101, but not in PlGF, distributions for higher values occurred in PE subjects. A progressive increase in the adjusted OR paralleled increased sFlt\u20101 and the sFlt\u20101\/PlGF ratio percentile values; no similar trend was noted for the PlGF percentiles. Increased sFlt\u20101 levels and sFlt\u20101\/PlGF ratio were significantly correlated with dysmenorrhea, hypertension, baby weight, and C\u2010section. In contrast, no correlation was found between PlGF and the PE\u2010associated features tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased sFlt\u20101 levels and corresponding sFlt\u20101\/PlGF ratio, but not circulating PlGF levels, constitute an independent risk factor for PE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13715","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T03:54:58Z","timestamp":1684900498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of the angiogenic factors sFlt\u20101, PlGF, and the sFlt\u20101\/PlGF ratio in preeclampsia and associated features"],"prefix":"10.1111","volume":"90","author":[{"given":"Marwa Ben Ali","family":"Gannoun","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Monastir  Monastir Tunisia"},{"name":"Department of Gynecology &amp; Obstetrics CHU 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