{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:58:20Z","timestamp":1780732700229,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A role for resistin in the pathogenesis of polycystic ovarian syndrome (PCOS) and related features were described for various ethnicities. As its expression is partly inherited, a role for <jats:italic>RETN<\/jats:italic> polymorphisms in regulating resistin levels and PCOS risk was shown, but with varied results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association of rs34124816 (\u2013537A&gt;C), rs1862513 (\u2013420C&gt;G), rs3219175 (\u2013358G&gt;A), rs3745367 (+299G&gt;A), rs3745369 (+1263G&gt;C), and rs1423096 (+4965C&gt;T) <jats:italic>RETN<\/jats:italic> SNPs with PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study subjects included 583 women with PCOS, and 713 eumenorrheic women serving as controls. Genotyping was done by real\u2010time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher minor allele frequency (MAF) of rs34124816, rs3219175, and rs3745369, and lower MAF of rs1862513 and rs1423096 were seen in PCOS cases. Reduced PCOS risk was found with rs3745367 minor\u2010allele homozygotes and rs1423096 minor\u2010allele homozygotes, while increased risk was linked with rs3745367 heterozygotes, and with rs3745369 heterozygotes and minor\u2010allele homozygotes. While it did not reach statistical significance, serum resistin levels were elevated in PCOS cases than in control women and major\u2010allele homozygotes of rs34124816 and rs1862513, and in rs1423096 minor\u2010allele\u2010containing carriers. Carriage of rs34124816 correlated positively with age and LH, whereas rs1862513 positively and rs3745367 negatively correlated with fasting glucose. Six\u2010locus (rs34124816\u2010rs1862513\u2010rs3219175\u2010rs3745367\u2010rs3745369\u2010rs1423096) haplotype analysis demonstrated a significant reduction in AGGGGG and a marked increase in AGGGCG haplotypes between cases and controls, thus assigning PCOS protective and susceptible nature to these haplotypes, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is the first to document the contribution of rs34124816 and rs1423096 <jats:italic>RETN<\/jats:italic> variants to the risk of PCOS. The varied association of <jats:italic>RETN<\/jats:italic> gene variants with PCOS suggests an ethnic contribution of <jats:italic>RETN<\/jats:italic> association with PCOS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13731","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T05:34:31Z","timestamp":1685165671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relation of resistin gene variants to resistin plasma levels and altered susceptibility to polycystic ovary syndrome: A case control study"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-0813","authenticated-orcid":false,"given":"Aminah M.","family":"Al\u2010Awadi","sequence":"first","affiliation":[{"name":"Department of Pediatrics College of Medicine Kuwait University  Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola 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Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-9757","authenticated-orcid":false,"given":"Wassim Y.","family":"Almawi","sequence":"additional","affiliation":[{"name":"School of Medicine Nazarbayev University Astana Kazakhstan"},{"name":"Facult\u00e9 des Sciences de Tunis Universit\u00e9 de Tunis El Manar  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-021-00879-w"},{"key":"e_1_2_8_4_1","first-page":"7","article-title":"Polycystic ovarian syndrome: insights into pathogenesis, diagnosis, prognosis, pharmacological and non\u2010pharmacological treatment","volume":"4","author":"Kabel AM","year":"2016","journal-title":"Pharm 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