{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:03:41Z","timestamp":1787753021855,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Secretory leukocyte protease inhibitor (SLPI) is an innate anti\u2010inflammatory and anti\u2010microbial peptide and produced in amnion of fetal membranes during pregnancy. However, studies on the association between SLPI levels in amniotic fluid and acute chorioamnionitis are limited. Afterbirth oral fluid (AOF) of the baby could be useful for representing the intra\u2010amniotic environment precisely just before delivery. This study aimed to determine the relationship between SLPI levels in AOF and acute histologic chorioamnionitis (HC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AOF of the baby was obtained during delivery from 24(0\/7) to 36(6\/7) weeks of gestational age (preterm group, <jats:italic>n<\/jats:italic>\u00a0=\u00a094) and from 37(0\/7) to 41(6\/7) weeks of gestational age (term group, <jats:italic>n<\/jats:italic>\u00a0=\u00a027) just after birth. SLPI expression levels among five classifications were compared to the intensity of acute HC as follows: no inflammation, acute subchorionitis, acute chorionitis, acute chorioamnionitis, and funisits. The SLPI and matrix metalloproteinase\u20108 (MMP\u20108) concentrations of AOF were determined using Enzyme Linked Immunosorbent Assay. Histologic examination of the placenta and membranes was performed after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SLPI concentrations in AOF inversely decreased according to the intensity of acute HC (161.62\u00a0ng\/mL in funisitis, 134.83\u00a0ng\/mL in acute chorioamnionitis, 749.35\u00a0ng\/mL in acute chorionitis, 953.05\u00a0ng\/mL in acute subchorionitis, and 1126.77\u00a0ng\/mL in no inflammation [<jats:italic>p<\/jats:italic>\u00a0=\u00a0.021]). The MMP\u20108 concentrations in AOF and maternal serum C\u2010reactive protein were the highest in funisitis. The SLPI\/ MMP\u20108 ratio was low in subgroup with acute chorioamnionitis and funisitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Along with increased MMP\u20108 levels, decreased SLPI levels in AOF of the baby could be an additional factor in predicting acute HC immediately after birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13733","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T01:13:21Z","timestamp":1686186801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Afterbirth oral fluid secretory leukocyte protease inhibitor decreased in acute histologic chorioamnionitis in preterm birth"],"prefix":"10.1111","volume":"90","author":[{"given":"Soo Ran","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Inha University College of Medicine Inha University Hospital  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Inha University College of Medicine Inha University Hospital  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050115"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.12.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/7.6.573"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12354"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(94)02023-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1610299"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.06.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.12.4.237.246"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.040"},{"issue":"4","key":"e_1_2_9_11_1","first-page":"29","article-title":"Chorioamnionitis and prematurity: a critical review","volume":"25","author":"Martinelli P","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.08.007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13573"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10051136"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1281904"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00448-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"issue":"4","key":"e_1_2_9_18_1","first-page":"394","article-title":"Fetal breathing movements. Characteristics and clinical significance","volume":"52","author":"Mars\u00e1l K","year":"1978","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199706000-00011"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000307075"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)99072-0"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.09.017"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.05.043"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T14:00:39Z","timestamp":1692453639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,5]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/aji.13733"],"URL":"https:\/\/doi.org\/10.1111\/aji.13733","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,5]]},"assertion":[{"value":"2023-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13733"}}