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The inflammation role in some of the main infertility\u2010related diseases has been studied, such as varicocele, spinal cord injury and obesity. Inflammation is the main response of the immune system to infection or cell damage, leading to intense inflammatory cytokine release during the loss of homeostasis. One of the first steps toward pro\u2010inflammatory cytokines release is the recognition of dangerous signals by the immune cells, including pathogen\u2010associated molecular patterns (PAMPs) and damage\u2010associated molecular patterns (DAMPs). These molecules can activate an important multiprotein complex, called inflammasome. Although these complexes have been studied during the last decades, their participation in male infertility has gained attention recently. Considering the inflammasome complex's high potential to be targeted for drug therapy, this review tries to shed light on current literature. Therefore, in the current review paper, we aimed to discuss the inflammasome complex activation, involvement in different male infertility conditions, and localization in the male reproductive tract.<\/jats:p>","DOI":"10.1111\/aji.13734","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:04:28Z","timestamp":1687241068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Insight toward inflammasome complex contribution to male infertility"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9763-1041","authenticated-orcid":false,"given":"Aram","family":"Minas","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Urology, Human Reproduction Section S\u00e3o Paulo Federal University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Vasconcelos 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