{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:24:24Z","timestamp":1781576664117,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>C\u2010reactive protein (CRP) is a marker for inflammation and its role as a possible biomarker for an early prediction of pre\u2010eclampsia (PE) is unclear. The present study investigates the levels of high\u2010sensitivity CRP (hs\u2010CRP) longitudinally across pregnancy in women with PE and compares them to women without PE (non\u2010PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>A total of 324 pregnant women [216 non\u2010PE and 108 PE women] were included in this study. Maternal blood was taken at four different intervals (V1 = 11\u201314 weeks, V2 = 18\u201322 weeks, V3 = 26\u201328 weeks, and V4 = at delivery).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal serum hs\u2010CRP levels were higher at V1, V2, and V3 (<jats:italic>p<\/jats:italic> &lt; .05 for all) in the PE group compared to the non\u2010PE group. The hs\u2010CRP levels were associated with maternal blood pressure throughout pregnancy. Maternal hs\u2010CRP levels did not differ among early and late onset PE. Higher maternal hs\u2010CRP levels were associated with the increased risk of PE in unadjusted model in early pregnancy. However, there was no significance after adjusting for confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest although the levels of hs\u2010CRP were higher in PE in early pregnancy, they are not associated with an increased risk of PE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13741","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:28:18Z","timestamp":1687656498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal profile of high\u2010sensitivity C\u2010reactive protein in women with pre\u2010eclampsia"],"prefix":"10.1111","volume":"90","author":[{"given":"Kamini","family":"Dangat","sequence":"first","affiliation":[{"name":"Mother and Child Health, Interactive Research School for Health Affairs Bharati Vidyapeeth (Deemed to be University) Pune Maharashtra 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