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Previous studies have failed to assess robust measurements of inflammatory markers across gestation, specifically in overweight\/ obese women in the context of preeclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>We measured 20 inflammatory markers in plasma via multiplex assay (ThermoFisher Inflammation 20 plex Human ProcartaPlex Panel) across the three trimesters of pregnancy in an existing cohort of overweight and obese women who developed preeclampsia (<jats:italic>n<\/jats:italic>\u00a0=\u00a037) and without preeclampsia (<jats:italic>n<\/jats:italic>\u00a0=\u00a074). Mann\u2013Whitney <jats:italic>U<\/jats:italic> tests examined differences in inflammatory marker concentrations between cases and controls. Repeated measures ANOVA tests were used to explore differences in inflammatory marker concentrations over time within cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pro\u2010inflammatory markers (IL\u20101\u03b1, IL\u20101\u03b2, IL\u20106, IFN\u2010\u03b1, IFN\u2010\u03b3, GM\u2010CSF, IL\u201012p70, IL\u201017\u03b1, TNF\u2010\u03b1, IL\u20108) and anti\u2010inflammatory markers (IL\u20104, IL\u201010, IL\u201013) were higher in the first and second trimester in participants who later developed preeclampsia compared to those who did not (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Only TNF\u2010\u03b1 and IL\u20108 remained elevated in the third trimester. Inflammatory markers did not change across pregnancy in preeclampsia cases but did increase across pregnancy in controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings diverge from prior studies, predominantly of non\u2010obese women, that report lower circulating concentrations of anti\u2010inflammatory cytokines in preeclampsia versus normotensive pregnancy, particularly by late pregnancy. We posit that women with overweight and obesity who develop preeclampsia entered pregnancy with a heightened pro\u2010inflammatory state likely related to obesity, which increased risk for preeclampsia. Further studies are needed to investigate if inflammatory maker profiles differ between obese and non\u2010obese women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13763","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T03:36:09Z","timestamp":1691033769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Inflammatory markers are elevated in early pregnancy, but not late pregnancy, in women with overweight and obesity that later develop preeclampsia"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-7539","authenticated-orcid":false,"given":"McKenzie K.","family":"Jancsura","sequence":"first","affiliation":[{"name":"College of Nursing Martha S. Pitzer Center for Women, Children and Youth The Ohio State University Columbus USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3543-8048","authenticated-orcid":false,"given":"Mandy J.","family":"Schmella","sequence":"additional","affiliation":[{"name":"School of Nursing University of Pittsburgh Pittsburgh USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6883-9684","authenticated-orcid":false,"given":"Nathan","family":"Helsabeck","sequence":"additional","affiliation":[{"name":"College of Nursing The Ohio State University Columbus USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0904-3299","authenticated-orcid":false,"given":"Shannon L.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"College of Nursing Martha S. 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