{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:34Z","timestamp":1787013814040,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760273"],"award-info":[{"award-number":["81760273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81360103"],"award-info":[{"award-number":["81360103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Abnormal metabolism of vitamin D was the primary mechanism in many pregnancy diseases. Our study was the first to examine the hypothesis that VDR gene polymorphisms contribute to the risk of gestational diabetes mellitus (GDM) in the Chinese population at high altitudes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>One hundred and eighteen women with GDM and 104 women with normal glucose tolerance (NGT) were included in this study using a case\u2010control design. Four single nucleotide polymorphisms (g.47879112G\u00a0&gt;\u00a0A, g.47846052C\u00a0&gt;\u00a0T, g.47844974A\u00a0&gt;\u00a0G, and g.47845054C\u00a0&gt;\u00a0A) of mother and fetus were genotyped.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Maternal and fetal frequency of the A allele of g.47879112G\u00a0&gt;\u00a0A was significantly increased in women with GDM than in those with NGT (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). A correlation between the AA homozygous genotype of g.47879112G\u00a0&gt;\u00a0A and GDM was noted. Compared with non\u2010carriers, A allele carriers showed higher fasting plasma insulin and two\u2010hour post\u2010challenge plasma glucose (2h\u2010PPG), and lower levels of vitamin D. Furthermore, both maternal and fetal 4\u2010marker haplotype ACCG were found to be significantly associated with GDM (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Association and haplotype analysis indicated that the A allele of g.47879112G\u00a0&gt;\u00a0A could be a risk factor for GDM development in the Chinese population at high altitudes. Additionally, the VDR gene polymorphism of the fetus and mother may have a synergistic effect. The VDR polymorphism is associated with an increased risk of GDM and may be useful for predicting the development of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.13778","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T02:46:39Z","timestamp":1698374799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between VDR genetic polymorphisms and risk of gestational diabetes mellitus in the Chinese population"],"prefix":"10.1111","volume":"90","author":[{"given":"Yantuanjin","family":"Ma","sequence":"first","affiliation":[{"name":"Kunming Medical Univesity  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Puer City  Puer 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