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In the past four decades, human leukocyte antigen (HLA)\u2010G and \u2010F have garnered significant attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>MEDLINE, EMBASE, Web of Science, and the Cochrane Trials Registry were searched from their inception dates until December 2022. Studies were selected following PRISMA guidelines. Meta\u2010analyses were used to assess the relationship of soluble HLA\u2010G (sHLA\u2010G) and <jats:italic>HLA\u2010G<\/jats:italic> 3\u2032\u2010untranslated region polymorphisms with recurrent miscarriage (RM) and recurrent implantation failure (RIF). Narrative synthesis was conducted to determine the association of RM with other single nucleotide polymorphisms (SNPs) and HLA\u2010G protein in tissues and of RIF with HLA\u2010F. Risk\u2010of\u2010bias was assessed using ROBINS\u2010I. Publication bias was assessed using Egger's and Begg's tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Finally, 42 articles were eligible for inclusion in the systematic review (32 in the meta\u2010analysis; 13 in narrative synthesis). We found a significant association between the 14\u2010bp ins\/del <jats:italic>HLA\u2010G<\/jats:italic> polymorphism and RM risk, but no definitive association with RIF risk. Women with RM had lower blood concentrations of sHLA\u2010G during pregnancy and non\u2010pregnancy than did controls. For women in the RIF group, no significant difference was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HLA\u2010G protein and gene expression levels may be closely related to RM. The relevance of HLA\u2010G to RIF is still being determined. A narrative synthesis of current studies has shown that HLA\u2010F is likely associated with RIF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13792","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T04:16:51Z","timestamp":1699244211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of human leukocyte antigen\u2010G and \u2010F with recurrent miscarriage and implantation failure: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2027-0120","authenticated-orcid":false,"given":"Nana","family":"Han","sequence":"first","affiliation":[{"name":"Clinical medical school Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Xia","sequence":"additional","affiliation":[{"name":"Gynecology Department 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