{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:12:01Z","timestamp":1778861521875,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Research question:<\/jats:title><jats:p>Decidualization is critical to the establishment of mouse normal pregnancy. The fibroblast\u2010like stromal cells in the process form polyploid multinucleated cells. Aurora kinase B (Aurora B) has previously been shown to regulate polyploidy in various cells. However, whether Aurora B regulates the formation of decidual cell polyploidization and its regulatory mechanisms remain poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p>Establish decidualization model of mouse primary endometrial stromal cells in vitro. Construct pseudopregnancy mouse models and delayed\u2010activation mouse models. Detect Aurora B and polyploidization related genes in mouse uteri treated by Aurora B specific inhibitor Barasertib and CPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In this study, we found that Aurora B was strongly expressed in endometrial stromal cells after implantation. Additionally, Aurora B was remarkably up regulated in the stromal cells of oil\u2010induced deciduomoa and in vitro decidualization. As an Aurora B specific inhibitor, Barasertib significantly inhibits the mRNA expression of <jats:italic>Prl8a2<\/jats:italic>, a marker of mouse decidualization. Furthermore, the protein levels of p\u2010Plk1, Survivin and p\u2010Cdk1 were inhibited by Barasertib. CPT\u2010induced DNA damage suppressed <jats:italic>Aurkb<\/jats:italic> (encodes Aurora B) expression, thus resulting in polyploidization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Our data shows that Aurora B is expressed in decidual stromal cells of implantation sites and plays a key role for mouse decidualization. The protein of Plk1, Survivn, and Cdk1 may participate in formation of decidual cell polyploidization during mouse decidualization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13793","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:19:45Z","timestamp":1697775585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Aurora kinase B on polyploidy and decidualization in mouse uterus"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3913-8835","authenticated-orcid":false,"given":"Peng\u2010Chao","family":"Wang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Taigu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Shan","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Oncology Department of Clinical Sciences Lund 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