{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:35:34Z","timestamp":1785216934480,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:00:00Z","timestamp":1705190400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The recurrence rate of intrauterine adhesions (IUA) was high. At present, there are few studies on the relationship between proinflammatory factors IL\u201017A and IL\u20106 and IUA. The expression of serum IL\u201017A and IL\u20106 in IUA patients and their predictive value for postoperative recurrence were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 90 IUA patients who underwent hysteroscopic adhesion lysis in our hospital from January 2020 to January 2023 were selected as the IUA group. Patients were divided into mild, moderate, and severe IUA groups. At the same time, 60 cases of secondary infertility patients with normal endometrium were selected as the control group. The clinical baseline characteristics and serum levels of IL\u201017A and IL\u20106 were compared between control group and IUA group. To analyze the correlation and predictive value of IL\u201017A and IL\u20106 expression levels with the recurrence rate of IUA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The preoperative levels of IL\u201017A and IL\u20106 in the IUA group were significantly higher than those in the control group. The higher the levels of inflammatory factors IL\u201017A and IL\u20106, the deeper the degree of IUA. Multivariate analysis showed that pregnancy, curettage history, IL\u201017A, and IL\u20106 levels were risk factors for IUA recurrence. In addition, the specificity and area under the curve of combining baseline data with postoperative serum IL\u201017A and IL\u20106 for predicting IUA were higher than those predicted separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The expression levels of serum IL\u201017A and IL\u20106 can be used as a value index to evaluate postoperative recurrence in IUA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13808","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T05:38:22Z","timestamp":1705297102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The predictive value of serum IL\u201017A and IL\u20106 expression in postoperative recurrence in patients with intrauterine adhesion"],"prefix":"10.1111","volume":"91","author":[{"given":"Xia","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Gynecology The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University  Changzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Chao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University  Changzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7274-2132","authenticated-orcid":false,"given":"Wen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University  Changzhou Jiangsu 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