{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:23:46Z","timestamp":1781619826877,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigated whether serum amyloid A (AA) levels can be used as a biomarker in patients with threatened abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>This prospective cohort study was conducted at the Antalya Training and Research Hospital, Department of Obstetrics and Gynecology, T\u00fcrkiye, between April and October 2023. Eighty\u2010eight pregnant women, 44 diagnosed with threatened\u00a0miscarriage (Group 1) and 44 healthy individuals (Group 2), were included in the study. Sociodemographic, obstetric, and laboratory parameters were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences were observed between the groups in terms of sociodemographic data (age, body mass index, education level, economic status, occupation status, smoking, and alcohol consumption). However, obstetric characteristics (number of pregnancies, living children, miscarriages, dilatation and curettage, gestational age on admission, and fetal crown\u2010rump length) and laboratory values including complete blood count, hematocrit, leukocyte, neutrophil, lymphocytes, platelet, hs\u2010C\u2010reactive protein, neutrophil\u2010lymphocyte and platelet\u2010lymphocyte ratio (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05), and serum AA values (7.49\u00a0\u00b1\u00a03.07 in Group\u00a01 vs. 9.46\u00a0\u00b1\u00a04.80 in Group 2, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.024) differed significantly. Receiver operating characteristic analysis showed that the area under the curve (AUC: 0.662) was statistically significant for serum AA (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.032), with a cut\u2010off value of \u22657.51 (95% [confidence interval] 0.516\u22120.749, sensitivity 65%, specificity 51%). The positive predictive value of serum AA for threatened miscarriage was 56.8%, and the negative predictive value 59.4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that serum AA can be used as a biomarker in the diagnosis of threatened miscarriage. Prospective studies involving more participants are now needed to confirm our results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13829","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T05:54:00Z","timestamp":1708754040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An evaluation of serum blood parameters and amyloid A levels in pregnant women with threatened miscarriage"],"prefix":"10.1111","volume":"91","author":[{"given":"Bekir Sitki","family":"Isenlik","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Cihan","family":"Sarica","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilgesu Cetinel","family":"Kaygun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ayd\u0131n Child and Women Hospital  Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-7908","authenticated-orcid":false,"given":"Hasan Ali","family":"Inal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2015150092"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1605898"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-016-1301-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.10.012"},{"issue":"8","key":"e_1_2_7_6_1","article-title":"Progestogen for treating threatened miscarriage","volume":"8","author":"Wahabi HA","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2016-0038"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.11.565"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000616"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2018-136004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181a207e3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.130"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000191899.84567.4d"},{"key":"e_1_2_7_15_1","article-title":"Progestogens for preventing miscarriage: a network meta\u2010analysis","volume":"4","author":"Devall AJ","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21564"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.03.028"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2014.058"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2015.10.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.12.021"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.25083\/2559.5555\/6.1.9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2019.1606171"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.28982\/josam.736881"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.346.15939"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101709693"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2022.0069"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231642"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198901000-00008"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181a207e3"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T04:39:59Z","timestamp":1712119199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/aji.13829"],"URL":"https:\/\/doi.org\/10.1111\/aji.13829","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]},"assertion":[{"value":"2024-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13829"}}