{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T13:21:41Z","timestamp":1771766501074,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The COVID\u201019 pandemic is an unprecedented health crisis that has affected in vitro fertilization practices globally. Previous studies have shown that SARS\u2010CoV\u20102 impacts the quality of embryos by inducing an immunological response in infertile patients. In this study, the early embryonic development of SARS\u2010CoV\u20102\u2010infected infertile patients was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010five SARS\u2010CoV\u20102 infected infertile patients and 258 controls were involved in this study. The major outcome parameters for the cycle were analyzed, including the number of oocytes, maturation oocytes, available embryos per cycle, and embryo morpho kinetic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From SARS\u2010CoV\u20102 infection until oocyte retrieval, it took an average of 6.63 days. The results revealed that the number of oocytes and high\u2010quality embryos on day 3 dramatically reduced in SARS\u2010CoV\u20102\u2010infected infertile patients. SARS\u2010CoV\u20102 was detected in the follicular fluid of three infertile patients. SARS\u2010CoV\u20102 infection had negatively impacted the number of oocytes in multivariate linear regression models. The early embryonic development in the SARS\u2010CoV\u20102 infection group had a noticeable delay from the six\u2010cell stage to blastocyst stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SARS\u2010CoV\u20102 infection reduced the number of oocytes and high\u2010quality embryos on day 3. It delays the early embryonic development from the six\u2010cell stage to blastocyst stage and has a negative impact on the quality of embryos.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13831","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T05:26:50Z","timestamp":1709702810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SARS\u2010CoV\u20102 infection negatively impacts on the quality of embryos by delaying early embryonic development"],"prefix":"10.1111","volume":"91","author":[{"given":"Linna","family":"Ma","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research Hainan Provincial Clinical Research Center for Thalassemia Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education Department of Reproductive Medicine the First Affiliated 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