{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:01:47Z","timestamp":1789678907427,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Seminal plasma hypersensitivity (SPH) is a rare and often misdiagnosed condition characterized by local and\/or systemic reactions to seminal plasma proteins following exposure to semen. We aimed to summarize key symptomatology, diagnostic features, and management options for SPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The databases PubMed, EMBASE, Web of Science, Google Scholar, and Cochrane Review were searched with key words \u201cseminal plasma hypersensitivity\u201d and \u201cseminal fluid allergy\u201d through September 2023. Exclusion criteria included non\u2010English articles, in vitro studies, publication before 1990, duplicates, and articles with no clinical relevance to SPH in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search yielded 53 articles for review. Of these, 60.5% described systemic SPH and 39.5% described localized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diagnosis of SPH relies on a thorough patient history and confirmatory skin prick testing. The use of IgE assays is controversial and less accurate for cases of localized SPH. Knowledge of disease immunopathology, systemic versus localized symptom presentation, patient preference, and desire to conceive should guide management options. Artificial insemination has the potential for severe adverse reactions in systemic SPH so necessitates extra procedural precautions. SPH does not appear to impair fertility. Additional research on specific allergens implicated in SPH can aid in the development of more targeted immunotherapy approaches with improved safety and efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13865","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T12:19:48Z","timestamp":1716380388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Seminal plasma hypersensitivity: A systematic review of clinical presentation, diagnostics, and management options"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8959-5201","authenticated-orcid":false,"given":"Kayla","family":"Schacher","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital at Downstate  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudar","family":"Dalloul","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital at Downstate  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgul","family":"Muneyyirci\u2010Delale","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital at Downstate  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13252"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.1069"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.11.085"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/msj.20283"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.04.067"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087830"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102222.2004.01962.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.18535\/jmscr\/v3i8.50"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.10.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20106749(90)90230\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0091\u20106749(05)80159\u20109"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346\u20108138.1991.tb03069.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091\u20106749(96)70219\u20101"},{"issue":"4","key":"e_1_2_9_17_1","first-page":"391","article-title":"Successful pregnancy in a woman with a human seminal plasma allergy. 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