{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:29:51Z","timestamp":1784042991292,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Endometriosis is a prevalent chronic gynecological disease linked to immune dysfunction. The protein T\u2010cell immunoglobulin and mucin domain\u2010containing protein 3 (TIM\u20103) plays a crucial role in immune system balance. Malfunction of TIM\u20103 may result in excessive immune activation and inflammatory tissue damage. Given TIM\u20103's established role in the development of cancer and autoimmune diseases, we decided to study its role in women suffering from endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Method<\/jats:title><jats:p>We included a total of 62 female patients, all of whom had undergone laparoscopic surgery. Of these, 47 had endometriosis and 15 did not. During surgery, we collected peritoneal fluid (PF) and peripheral blood (PB) samples from every patient for analysis using flow cytometry. To mark the samples, we used a panel of monoclonal antibodies and examined TIM\u20103 expression in their immune cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Endometriosis patients in PB demonstrated a significantly lower percentage of CD56+ T cells with TIM\u20103 expression. As endometriosis progressed through its stages, this expression lessened. This decrease was particularly notable in women with stage III\/IV endometriosis. Additionally, both women diagnosed with intestinal endometriosis and those with recent endometriosis diagnoses showed a significantly reduced percentage of CD56+ T cells expressing TIM\u20103.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with endometriosis exhibit diminished TIM\u20103 expression within circulating T cells. This warrants further investigation to discern whether it contributes to the progression of endometriosis, potentially through the amplification of autoreactive T cells and inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13887","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T13:51:03Z","timestamp":1719237063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["TIM\u20103 Expression in Endometriosis"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2537-7026","authenticated-orcid":false,"given":"Jos\u00e9","family":"Louren\u00e7o Reis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology LUZ SA\u00daDE Hospital da Luz Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Martins","sequence":"additional","affiliation":[{"name":"CHRC, NOVA Medical 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Miguel","family":"Borrego","sequence":"additional","affiliation":[{"name":"CHRC, NOVA Medical School Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM Universidade Nova de Lisboa  Lisboa Portugal"},{"name":"Immunology Department NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas NMS|FCM Universidade Nova de Lisboa  Lisboa Portugal"},{"name":"Department of Imunoallergy LUZ SA\u00daDE, Hospital da Luz  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-2741","authenticated-orcid":false,"given":"Jorge","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology LUZ SA\u00daDE Hospital da Luz Lisboa  Lisboa Portugal"},{"name":"CHRC, NOVA Medical School Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM Universidade Nova de Lisboa  Lisboa Portugal"},{"name":"Immunology Department NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas NMS|FCM Universidade Nova de Lisboa  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