{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:35:21Z","timestamp":1780504521639,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to investigate the clinical relevance of anti\u2010prothrombin antibodies (aPT) and anti\u2010phosphatidylserine\/prothrombin antibodies (aPS\/PT) in relation to pregnancy outcomes and coagulation parameters, as well as immune markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 477 pregnant women with experienced at least one spontaneous miscarriage who were tested for aPT and aPS\/PT antibodies, and compared their clinical characteristics, coagulation indicators, immune biomarkers, and pregnancy outcomes to assess the diagnostic accuracy of these antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the aPT IgG and the aPS\/PT IgM were independently associated with increased risk of pregnancy loss, with odds ratios (ORs) of 1.055 (95% confidence interval [CI]: 1.009\u20131.103, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017) and 1.041 (95% CI: 1.015\u20131.067, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), respectively. Moreover, we found that the aPS\/PT IgM had a higher diagnostic performance than the aPT IgG, as indicated by the AUC of 0.663 and 0.593, respectively. The pregnancy loss rate was positively correlated with the level of aPS\/PT IgM, while the aPT IgG is not. We also found that in the pregnancy loss group, aPT IgG showed negative correlations with prothrombin time (PT); aPS\/PT IgM showed positive correlations with aPS\/PT IgG. However, none of aPT IgG, aPT IgM, aPS\/PT IgM, or aPS\/PT IgG was related to other adverse pregnancy outcomes, such as preterm delivery, fetal growth restriction (FGR), or preeclampsia (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that aPT IgG and aPS\/PT IgM are independent risk factors for pregnancy loss, especially aPS\/PT IgM, which has a positive linear correlation with pregnancy loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13890","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T11:46:48Z","timestamp":1720007208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Correlation of Anti\u2010Phosphatidylserine\/Prothrombin and Anti\u2010Phosphatidylserine Antibodies with Pregnancy Outcomes"],"prefix":"10.1111","volume":"92","author":[{"given":"Junmiao","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics The Third Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics The Third Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruru","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics The Third Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3566-8697","authenticated-orcid":false,"given":"Zhuhua","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics The Third Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2019000043"},{"issue":"6","key":"e_1_2_10_3_1","first-page":"1058","article-title":"Correlation of Anti\u2010Phosphatidylserine\/Prothrombin Antibodies With Unexplained Recurrent Miscarriages","volume":"55","author":"Yao Z. 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