{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:20:03Z","timestamp":1792405203592,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>This study aimed to evaluate the predictive value of delta neutrophil index (DNI), a peripheral blood parameter, on perinatal outcomes in pregnant women with systemic lupus erythematosus (SLE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>One hundred eighty\u2010one participants, 78 pregnant women with SLE, and 103 healthy pregnant women were included in this retrospective study. Peripheral blood parameters including neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), and DNI taken in the first trimester were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NLR, PLR, and DNI were significantly higher in the SLE group (<jats:italic>p<\/jats:italic> = 0.027, <jats:italic>p<\/jats:italic> = 0.007, <jats:italic>p<\/jats:italic> = 0.0001, respectively). The same parameters were not found to be significant in determining disease activity in pregnant women with SLE (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). When the predictive value of DNI for SGA in pregnancies with SLE was evaluated by receiver operating characteristic curve (ROC), the area under the ROC curve (AUC) was 0.666 (95% CI; 0.544\u20130.788, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.018) with 84.6% sensitivity, 53.8% specificity, 56.0% PPV, and 78.1% NPV at a cut\u2010off value of 0.16. The predictive value of DNI according to ROC for stillbirth in pregnancies with SLE was AUC 0.731 (95% CI: 0.539\u20130.923, <jats:italic>p<\/jats:italic> = 0.019) with a cut\u2010off value of 0.17, sensitivity of 90%, specificity of 51.5%, PPV of 58.5%, and NPV of 87.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although DNI's prediction of SGA and stillbirth in pregnant women with SLE is encouraging, it needs more evidence from prospective studies with larger series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13894","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T11:46:47Z","timestamp":1720007207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictability of the Delta Neutrophil Index and Other Blood Parameters on Perinatal Outcomes in Pregnant Women With Systemic Lupus Erythematosus"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-2837","authenticated-orcid":false,"given":"\u015e\u00fckran","family":"Do\u011fru","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Necmettin Erbakan University Medical School of Meram  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-9165","authenticated-orcid":false,"given":"Fatih","family":"Akku\u015f","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Necmettin Erbakan University Medical School of Meram  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huriye","family":"Ezveci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Necmettin Erbakan University Medical School of Meram  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fikriye Karanfil","family":"Yaman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Perinatology Necmettin Erbakan University Medical School of Meram  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selman","family":"Parlak","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Necmettin Erbakan University Medical School of Meram  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dclfet Sena","family":"Metin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Necmettin Erbakan University Medical School of Meram  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Bah\u00e7eci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Necmettin Erbakan University Medical School of Meram  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Acar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Necmettin Erbakan University Medical School of Meram  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.12.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020909"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.02.009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-020-05039-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-2139-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2019.09.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2019.09.002"},{"issue":"7","key":"e_1_2_10_9_1","first-page":"11026","article-title":"Neutrophil\u2010Lymphocyte Ratio in Systemic Lupus Erythematosus Disease: A Retrospective Study","volume":"8","author":"Li L.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1091136"},{"issue":"3","key":"e_1_2_10_11_1","first-page":"241","article-title":"Delta Neutrophil Index in Automated Immature Granulocyte Counts for Assessing Disease Severity of Patients with Sepsis","volume":"38","author":"Nahm C. H.","year":"2008","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182454acf"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148799"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173382"},{"issue":"3","key":"e_1_2_10_15_1","article-title":"Increased Delta Neutrophil Index in Women With Severe Preeclampsia","volume":"78","author":"Cho H. Y.","year":"2017","journal-title":"American Journal of Reproductive Immunology (New York, NY : 1989)"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1760833"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15542"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313499957"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102651"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13259"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08893-y"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-018-0242-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.012"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06718-7"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04823-8"},{"issue":"3","key":"e_1_2_10_28_1","first-page":"236","article-title":"Haematological Abnormalities in Systemic Lupus Erythematosus","volume":"39","author":"Aleem A.","year":"2014","journal-title":"Acta Reumatologica Portuguesa"},{"issue":"3","key":"e_1_2_10_29_1","first-page":"269","article-title":"Neutrophil\u2010 and Platelet\u2010to\u2010Lymphocyte Ratios Are Correlated With Disease Activity in Rheumatoid Arthritis","volume":"61","author":"Fu H.","year":"2015","journal-title":"Clinical Laboratory"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.12.007"},{"issue":"2","key":"e_1_2_10_31_1","first-page":"1547","article-title":"Predictive Value of the Neutrophil\u2010to\u2010Lymphocyte Ratio and Hemoglobin Insystemic Lupus Erythematosus","volume":"16","author":"Yu H.","year":"2018","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.04.006"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2018.07.008"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2021.1946022"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06169-0"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2023.103978"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.2022-1135"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-017-1066-y"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2022.2040968"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1363-2855"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1509-3676"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T03:36:23Z","timestamp":1722310583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/aji.13894"],"URL":"https:\/\/doi.org\/10.1111\/aji.13894","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13894"}}