{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:23:15Z","timestamp":1789190595292,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Achieving pregnancy through in vitro fertilization (IVF) remains a challenge, with less than one\u2010third of women succeeding. There is a pressing need for reliable predictive tools to assess the likelihood of post\u2010IVF pregnancy. While some serum inflammatory biomarkers have been investigated for their predictive potential, substantial knowledge gaps persist. This study examined the utility of different inflammatory markers in predicting IVF outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>Inflammatory markers including the white blood cell count, neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet count, mean platelet volume, platelet distribution width, platelet\u2010to\u2010lymphocyte ratio (PLR), C\u2010reactive protein (CRP), erythrocyte sedimentation rate, and vitamin D<jats:sub>3<\/jats:sub> were assessed. Study outcomes were chemical pregnancy (positive serum beta\u2010human chorionic gonadotropin 2 weeks post\u2010embryo transfer), clinical pregnancy (detection of pregnancy sac via transvaginal ultrasonography), and viable pregnancy (detection of fetal heart rate). Univariate and multivariate logistic regression analyses were conducted, with multivariate analysis incorporating age, body mass index, infertility duration, type, and etiology, as well as all studied serum inflammatory markers, embryo count, stage, quality, and endometrial thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower NLR (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, odds ratio [OR]\u00a0=\u00a00.372 [0.247\u20130.559]) and CRP (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.035, odds ratio\u00a0=\u00a00.956 [0.916\u20130.997]) predicted chemical pregnancy in univariate analysis, with NLR maintaining significance in multivariate analysis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.022, OR\u00a0=\u00a00.319 [0.120\u20130.848]). Lower NLR (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, OR\u00a0=\u00a00.309 [0.198\u20130.482]) and PLR (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.013, OR =\u00a00.994 [0.990\u20130.999]) predicted clinical pregnancy, with NLR surviving multivariate analysis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005, OR = 0.217 [0.075\u20130.626]). Lower NLR (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, OR = 0.320 [0.198\u20130.516]) also predicted viable pregnancy, maintaining statistical significance in multivariate analysis (<jats:italic>p<\/jats:italic> = 0.002, OR = 0.177 [0.058\u20130.541]). Other studied inflammatory markers did not predict IVF outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NLR emerged as a robust independent predictor of pregnancy attainment after IVF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13900","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T07:18:11Z","timestamp":1721891891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predicting the Outcomes of In Vitro Fertilization Using Baseline Maternal Serum Inflammatory Markers: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"92","author":[{"given":"Sedigheh","family":"Hantoushzadeh","sequence":"first","affiliation":[{"name":"Vali\u2010e\u2010Asr Reproductive Health Research Center Family Health Research Institute Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzie","family":"Poorabdoli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Family Health Research Institute Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-0319","authenticated-orcid":false,"given":"Mohammadamin","family":"Parsaei","sequence":"additional","affiliation":[{"name":"Maternal, Fetal &amp; Neonatal Research Center Family Health Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikan","family":"Zargarzadeh","sequence":"additional","affiliation":[{"name":"Maternal Fetal Care Center Boston Children's Hospital Harvard Medical School  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Masoumi","sequence":"additional","affiliation":[{"name":"Vali\u2010e\u2010Asr Reproductive Health Research Center Family Health Research Institute Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh Eslami","family":"Khotbesara","sequence":"additional","affiliation":[{"name":"Vali\u2010e\u2010Asr Reproductive Health Research Center Family Health Research Institute Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-9507","authenticated-orcid":false,"given":"Azadeh","family":"Tarafdari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Family Health Research Institute Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Infertility Prevalence Estimates: 1990\u20132021","author":"World Health Oragnization","year":"2023"},{"issue":"2","key":"e_1_2_10_3_1","first-page":"76","article-title":"Impact of Various Parameters as Predictors of the Success Rate of In Vitro Fertilization","volume":"16","author":"Dabbagh Rezaeiyeh R.","year":"2022","journal-title":"International Journal of Fertility and Sterility"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq015"},{"key":"e_1_2_10_5_1","volume-title":"In Vitro Fertilization","author":"Choe J.","year":"2024"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep477"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei253"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2022.2125296"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01924-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2018.02.019"},{"issue":"1","key":"e_1_2_10_11_1","first-page":"71","article-title":"The Role of Inflammatory Hematological Markers in Predicting IVF Success","volume":"25","author":"Ozgu\u2010Erdinc A. 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