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Originally, highlighting the importance of poor placentation for early\u2010onset preeclampsia, the revised two\u2010stage model explains late\u2010onset preeclampsia as well, which is often preceded by normal placentation. We discuss how cellular senescence in the placenta may fit with the framework of the revised two\u2010stage model of preeclampsia pathophysiology and summarize potential cellular and molecular mechanisms, including effects on placental and maternal endothelial function. Cellular senescence may occur in response to inflammatory processes and oxidative, mitochondrial, or endoplasmic reticulum stress and chronic stress induce accelerated, premature placental senescence. In preeclampsia, both circulating and tissue\u2010based senescence markers are present. We suggest that aspirin prophylaxis, commonly recommended from the first trimester onward for women at risk of preeclampsia, may affect placentation and possibly mechanisms of placental senescence, thus attenuating the risk of preeclampsia developing clinically. We propose that biomarkers of placental dysfunction and senescence may contribute to altered preventive strategies, including discontinuation of aspirin at week 24\u201328 depending on placenta\u2010associated biomarker risk stratification.<\/jats:p>","DOI":"10.1111\/aji.13904","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T03:24:59Z","timestamp":1721877899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Placental Senescence and the Two\u2010Stage Model of Preeclampsia"],"prefix":"10.1111","volume":"92","author":[{"given":"Meryam","family":"Sugulle","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Division of Obstetrics and Gynaecology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bendik 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