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Viral infections during pregnancy have been linked to central nervous system development impairments and disorders such as autism. Changes in the structure and function of the respiratory, immune, and visceral systems have also been reported. SARS\u2010CoV\u20102 infection during pregnancy has been linked with increased risks of stillbirth and preterm birth. However, the mechanisms involved remain unclear and may include cytokine storms, macrophage mediation, genetic mutations, methylation, and other epigenetic changes. Exploring the protective effects of antiviral treatment and other interventions in animal and clinical studies may help improve outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SARS\u2010CoV\u20102 infection during pregnancy activates the maternal\u2013fetal immune interface through vertical transmission, and has short\u2010 and long\u2010term effects on fetal development, including the central nervous system. Future long\u2010term studies may help provide evidence that can inform interventions to reduce the risk of adverse outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13911","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T08:10:07Z","timestamp":1723104607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Maternal SARS\u2010CoV\u20102 Infection During Pregnancy on Fetal Development"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8183-8073","authenticated-orcid":false,"given":"Jianan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound Shengjing Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shengjing Hospital of China 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