{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:01:27Z","timestamp":1787166087800,"version":"build-2736575974"},"reference-count":137,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The emergence of the severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) has led to the global COVID\u201019 pandemic, significantly impacting the health of pregnant women. Obstetric populations, already vulnerable, face increased morbidity and mortality related to COVID\u201019, aggravated by preexisting comorbidities. Recent studies have shed light on the potential correlation between COVID\u201019 and preeclampsia (PE), a leading cause of maternal and perinatal morbidity worldwide, emphasizing the significance of exploring the relationship between these two conditions. Here, we review the pathophysiological similarities that PE shares with COVID\u201019, with a particular focus on severe COVID\u201019 cases and in PE\u2010like syndrome cases related with SARS\u2010CoV\u20102 infection. We highlight cellular and molecular mechanistic inter\u2010connectivity between these two conditions, for example, regulation of renin\u2013angiotensin system, tight junction and barrier integrity, and the complement system. Finally, we discuss how COVID\u201019 pandemic dynamics, including the emergence of variants and vaccination efforts, has shaped the clinical scenario and influenced the severity and management of both COVID\u201019 and PE. Continued research on the mechanisms of SARS\u2010CoV\u20102 infection during pregnancy and the potential risk of developing PE from previous infections is warranted to delineate the complexities of COVID\u201019 and PE interactions and to improve clinical management of both conditions.<\/jats:p>","DOI":"10.1111\/aji.13915","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T07:23:42Z","timestamp":1723447422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Preeclampsia in the Context of COVID\u201019: Mechanisms, Pathophysiology, and Clinical Outcomes"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-4256","authenticated-orcid":false,"given":"Guilherme M.","family":"Nobrega","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medical Sciences University of Campinas  Campinas S\u00e3o Paulo 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