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Presently, vaccination stands as a critical preventive measure for mitigating infection\u2010related risks. Although the initial clinical trials for the COVID\u201019 vaccines excluded pregnant women, subsequent investigations have indicated mRNA vaccinations' effectiveness and short\u2010term safety during pregnancy. However, there is a lack of information regarding the potential biodistribution of the vaccine mRNA during pregnancy and lactation. Recent findings indicate that COVID\u201019 vaccine mRNA has been detected in breast milk, suggesting that its presence is not confined to the injection site and raises the possibility of similar distribution to the placenta and the fetus. Furthermore, the potential effects and responses of the placenta and fetus to the vaccine mRNA are still unknown. While potential risks might exist with the exposure of the placenta and fetus to the COVID\u201019 mRNA vaccine, the application of mRNA therapies for maternal and fetal conditions offers a groundbreaking prospect. Future research should leverage the unique opportunity provided by the first\u2010ever application of mRNA vaccines in humans to understand their biodistribution and impact on the placenta and fetus in pregnant women. Such insights could substantially advance the development of safer and more effective future mRNA\u2010based therapies during pregnancy.<\/jats:p>","DOI":"10.1111\/aji.13934","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T12:08:17Z","timestamp":1728648497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["COVID\u201019 Vaccine mRNA Biodistribution: Maternal and Fetal Exposure Risks"],"prefix":"10.1111","volume":"92","author":[{"given":"Connie","family":"Zhong","sequence":"first","affiliation":[{"name":"New York University\u2010Grossman Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koral","family":"Cohen","sequence":"additional","affiliation":[{"name":"New York University\u2010Grossman Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Lin","sequence":"additional","affiliation":[{"name":"Women and Children's Research Laboratory Departments of Foundations of Medicine New York University\u2010Grossman Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Schiller","sequence":"additional","affiliation":[{"name":"New York University\u2010Grossman Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-3467","authenticated-orcid":false,"given":"Surendra","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2167-5712","authenticated-orcid":false,"given":"Nazeeh","family":"Hanna","sequence":"additional","affiliation":[{"name":"Women and Children's Research Laboratory Departments of Foundations of Medicine New York University\u2010Grossman Long Island School of Medicine  Mineola New York USA"},{"name":"Department of Pediatrics Division of Neonatology New York University Langone Hospital\u2014Long Island New York University\u2010Grossman Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.679344"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13317"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120586"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2021.05.011"},{"key":"e_1_2_11_6_1","unstructured":"CDC: COVID\u201019 Vaccination for People Who Are Pregnant or Breastfeeding https:\/\/www.cdc.gov\/covid\/vaccines\/pregnant\u2010or\u2010breastfeeding.html#:~:text=Everyone%20ages%206%20months%20and pregnancy%20is%20safe%20and%20effective."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13713"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.06.023"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010020\u20100669\u20106"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm\u20102015\u20100012"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c04829"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.10.011"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9101496"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.12.108"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n627"},{"key":"e_1_2_11_18_1","unstructured":"European Medicines Agency. 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