{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:44Z","timestamp":1753878404487,"version":"3.41.2"},"reference-count":84,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Preterm birth (PTB) is a significant cause of maternal and neonatal morbidity and mortality worldwide. However, the effectiveness of progesterone (P4) which is clinically used for PTB management remains controversial and necessitates research into new therapeutic options<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>In the current study, we investigated the effectiveness of two chlorophyll derivatives, pheophorbide a (PBa) and pheophytin a (PTa), in counteracting PTB. Timed\u2010pregnant mice (gestation day 17\u00a0\u00b1\u00a00.5) received lipopolysaccharide (LPS) (25\u00a0\u00b5g\/mouse) or phosphate\u2010buffered saline (PBS) intraperitoneally, with PBa, PTa, progesterone (P4), and co\u2010administration of P4 and ibuprofen (IBP), administered orally 2\u00a0h prior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LPS group experienced PTB and 100% fetal mortality, whereas the PBa and PTa groups showed a delayed onset of LPS\u2010induced PTB, with significantly decreased PTB rate and fetal mortality. In addition, PBa and PTa suppressed LPS\u2010induced pro\u2010inflammatory cytokines and NF\u2010\u03baB transcription factor while increasing anti\u2010inflammatory cytokines in the placenta and uterus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that the chlorophyll derivatives, PBa and PTa increase fetal survival in infection\u2010induced PTB and demonstrate greater efficacy than P4 in preventing PTB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70000","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T09:46:06Z","timestamp":1729244766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chlorophyll Derivatives Exert Greater Potency Over Progesterone in the Prevention of Infection\u2010Induced Preterm Birth in Murine Models"],"prefix":"10.1111","volume":"92","author":[{"given":"Adaeze 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