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Maternal antibodies, however, can inhibit antibody production in neonates. We sought to determine the effects of maternal vaccination on neonatal immune response to a SARS\u2010CoV\u20102 mRNA vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>We hypothesized that mRNA\u2010lipid nanoparticles (LNP) vaccination allows for a de novo neonatal antibody response even in the presence of vertically transmitted maternal antibodies. Female mice were vaccinated with SARS\u2010CoV\u20102 spike receptor binding domain (RBD) mRNA\u2010LNPs. Mice were then bred, and 21\u2010day\u2010old pups were inoculated with the same mRNA\u2010LNPs. Spike\u2010specific IgG ELISAs were performed using mouse serum. A SARS\u2010CoV\u20102 spike protein peptide library to perform peptide ELISAs characterized high affinity binding domains within the spike protein. Results were analyzed with one\u2010way ANOVAs with Tukey's multiple comparisons tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to pups of unvaccinated dams, there were high levels of spike\u2010specific IgG detected in the pups of vaccinated dams at 3 weeks of life (<jats:italic>p<\/jats:italic> &lt; 0.0001). After neonatal vaccination, pups of unvaccinated dams had higher spike\u2010specific serum IgG than pups of vaccinated dams at 12 weeks of life (<jats:italic>p<\/jats:italic> &lt; 0.001). Antibody specificity to peptide moieties within spike RBD were similar when comparing a vaccinated dam to her pup at Week 3 of life, with different binding affinities observed in the pups by Week 15 of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010existing maternal antibodies may partially blunt the initial neonatal antibody response to mRNA\u2010LNPs vaccination. This vaccine strategy, however, does not prohibit the subsequent development of a broad range of RBD antibody specificities that may be protective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70001","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T13:00:37Z","timestamp":1729602037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neonatal SARS\u2010CoV\u20102 mRNA Vaccination Efficacy Is Influenced by Maternal Antibodies"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-8794","authenticated-orcid":false,"given":"Amy","family":"Schumer","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences University of Vermont Medical Center Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Bonney","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences University of Vermont Medical Center Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Harby","sequence":"additional","affiliation":[{"name":"Biological Sciences University of Vermont Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devdoot","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Vermont Medical Center Burlington Vermont USA"},{"name":"Department of Electrical and Biomedical Engineering University of Vermont Medical Center Burlington Vermont USA"},{"name":"UVM Cancer Center University of Vermont Medical Center Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.WHO Coronavirus (COVID\u201019) Dashboard.World Health Organization updated November 2 2023 accessed November 6 2023 https:\/\/covid19.who.int\/."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.08.054"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6944e3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.202604"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004339"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.1050"},{"key":"e_1_2_10_8_1","unstructured":"American Academy of Pediatrics.Children and COVID\u201019: State\u2010Level Data Report American Academy of Pediatrics updated May 16 2023 accessed November 6 2023 https:\/\/www.aap.org\/en\/pages\/2019\u2010novel\u2010coronavirus\u2010covid\u201019\u2010infections\/children\u2010and\u2010covid\u201019\u2010state\u2010level\u2010data\u2010report\/#:~:text=Since%20the%20pandemic%20began%2C%20children %25%20of%20the%20US%20population."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7111e2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31822e5c02"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708630"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2021.100467"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004621"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2216480"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(51)80131\u20108"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3633"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002301"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002588"},{"key":"e_1_2_10_19_1","unstructured":"A. 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