{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:54:31Z","timestamp":1792601671371,"version":"4.5.0"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI141501"],"award-info":[{"award-number":["R01AI141501"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Limited studies have investigated the role of the microbiota in hypertensive disorders of pregnancy (HDP), particularly preeclampsia, which often results in preterm birth. We evaluated 23 studies that explored the relationship between gut, vaginal, oral, or placental microbiotas and HDP. Scopus, ProQuest Health Research Premium Collection, ProQuest Nursing &amp; Allied Health Database, EBSCO, and Ovid were searched for relevant literature. Majority (18) of studies focused on the gut microbiota, and far fewer examined the oral cavity (3), vagina (3), and placenta (1). One study examined the gut, oral, and vaginal microbiotas. The consensus highlights a potential role for microbiota dysbiosis in preeclampsia and HDP. Especially in the third trimester, preeclampsia is associated with gut dysbiosis\u2014deficient in beneficial species of\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    ,\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    , and\n                    <jats:italic>Coprococcus<\/jats:italic>\n                    but enriched with pathogenic\n                    <jats:italic>Campylobacterota<\/jats:italic>\n                    and\n                    <jats:italic>Candidatus Saccharibacteria<\/jats:italic>\n                    , with low community\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010diversity. Similarly, the preeclamptic vaginal and oral microbiotas are enriched with bacterial vaginosis and periodontal disease\u2010associated species, respectively. The trend is also observed in the placenta, which is colonized by gastrointestinal, respiratory tract, and periodontitis\u2010related pathogens. Consequently, a chronic proinflammatory state that adversely impacts placentation is implicated. These observations however require more mechanistic studies to establish the timing of the preceding immune dysfunction and any causality.\n                  <\/jats:p>","DOI":"10.1111\/aji.70003","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T08:20:17Z","timestamp":1729671617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Scoping Review of Microbiota Dysbiosis and Risk of Preeclampsia"],"prefix":"10.1111","volume":"92","author":[{"given":"Madeleine M.","family":"Jordan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Basic Science and Translational Research University of Texas Medical Branch  Galveston Texas 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