{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:26:39Z","timestamp":1769912799363,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Research has suggested a link between recurrent pregnancy loss (RPL) and cell\u2010mediated immunity dysregulation. We aimed to determine if a history of RPL is associated with diagnosis of a cell\u2010mediated autoimmune condition (AIC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>A retrospective cohort study was conducted using the TriNetX research network. The RPL group had \u22653 spontaneous or missed abortions. Controls had at least one pregnancy but no diagnosis of RPL. Propensity score matching was used for age, race, and ethnicity. <jats:italic>Z<\/jats:italic>\u2010test and relative risk analysis investigated the relationship between RPL and subsequent AIC diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred twenty\u2010eight thousand three hundred seventy\u2010six patients were included in each cohort. RPL was associated with an increased risk for an AIC composite (RR 1.60, 95% CI [1.51, 1.69]), Crohn's disease, Graves\u2019 disease, Hashimoto's thyroiditis, multiple sclerosis, rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, and ulcerative colitis, but not psoriatic arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using a large research database of patients with RPL, we were able to demonstrate that an antecedent diagnosis of RPL is associated with increased risk of subsequent diagnosis of an AIC, often between 1 and 10\u00a0years after RPL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70006","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T10:48:15Z","timestamp":1729939695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autoimmune Condition Diagnosis Following Recurrent Pregnancy Loss"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8259-635X","authenticated-orcid":false,"given":"Marisa R.","family":"Imbroane","sequence":"first","affiliation":[{"name":"School of Medicine Case Western Reserve University  Cleveland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia","family":"LeMoine","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology MetroHealth\/Case Western Reserve (University Hospitals)  Cleveland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly S.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology MetroHealth Division of Maternal Fetal Medicine  Cleveland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"76","article-title":"Recurrent Pregnancy Loss: Etiology, Diagnosis, and Therapy","volume":"2","author":"Ford H. 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