{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:45:36Z","timestamp":1791963936069,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705900"],"award-info":[{"award-number":["2023YFC2705900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>Investigating the impact of severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) infection on female fertility and laboratory outcomes in patients undergoing assisted reproductive technology (ART) treatment who were initially uninfected but later became infected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods of the Study<\/jats:title>\n                    <jats:p>This self\u2010controlled study included 197 patients who underwent repeated oocyte retrieval before and after SARS\u2010CoV\u20102 infection between March 2021 and April 2023, of which 117 used the same ovarian stimulation protocol within a consistent age range. We evaluated the ovarian reserve, ovarian response, and laboratory outcomes in patients before and after SARS\u2010CoV\u20102 infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ovarian reserve (follicle\u2010stimulating hormone [FSH], luteinizing hormone [LH], estrogen [E\n                      <jats:sub>2<\/jats:sub>\n                      ], anti\u2010M\u00fcllerian hormone [AMH], antral follicle count [AFC]), ovarian response (total Gn dosage, duration of Gn administration, number of follicles \u226514\u00a0mm on trigger day, number of retrieved oocytes), and laboratory outcomes (cleavage stage good\u2010quality embryo rate, blastocyst formation rate, and cycle freezing rate) showed no significant differences before and after SARS\u2010CoV\u20102 infection in 117 patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.05). When stratified by age, the \u2264 35\u00a0years group showed a higher two pronuclei (2PN) fertilization rate post\u2010infection, while the &gt;35\u00a0years group had increased mature metaphase II (MII) oocyte and blastocyst stage good\u2010quality embryo rates. Additionally, upon stratified by the time interval between SARS\u2010CoV\u20102 infection and ART treatment, in the \u2264 3\u00a0months group, there was an increased post\u2010infection MII oocyte rate, 2PN fertilization rate, and blastocyst stage good\u2010quality embryo rate. Meanwhile, no significant differences were found in any indicators when the interval exceeded three\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggested that undergoing IVF\/ICSI treatment after recovering from COVID\u201019 may not adversely affect female fertility and laboratory outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70012","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T06:52:54Z","timestamp":1731480774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Impact of Omicron Variant Infection on Female Fertility and Laboratory Outcomes: A Self\u2010Controlled Study"],"prefix":"10.1111","volume":"92","author":[{"given":"Yu\u2010Ling","family":"Hu","sequence":"first","affiliation":[{"name":"The Reproductive Center Sichuan Jinxin Xinan Women and Children's Hospital  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Jia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Women and Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Toxicology Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Yu","family":"Lv","sequence":"additional","affiliation":[{"name":"The Reproductive Center Sichuan Jinxin Xinan Women and Children's Hospital  Chengdu Sichuan 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Public Health, Chongqing Medical University  Chongqing China"},{"name":"Department of Pharmacology Academician Workstation Changsha Medical University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Hua","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Academician Workstation Changsha Medical University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Hong","family":"Geng","sequence":"additional","affiliation":[{"name":"The Reproductive Center Sichuan Jinxin Xinan Women and Children's Hospital  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Jiao","family":"Xu","sequence":"additional","affiliation":[{"name":"The Reproductive Center Sichuan Jinxin Xinan Women and Children's Hospital  Chengdu Sichuan 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