{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:25:23Z","timestamp":1753878323829,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In recent years antiphospholipid syndrome (APS) as well as antiphospholipid antibodies (aPL) prevalence has demonstrated an upward trend in women during reproductive age. There is a lack of data concerning its effects on women with grand multiparity (GMP) (parity \u22655). Hence, this study aimed to assess pregnancy outcomes among GMP aPL\/APS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>We retrospectively assembled the births of GMP women with aPL\/APS, between 2017 and 2022 in the Sheba Medical Center. We compared their deliveries with those of two control groups: (1) the \u201caPL\/APS\u2010controls\u201d\u2014of pregnant women with aPL\/APS and parity &lt;5. (2) The \u201cGMP\u2010controls\u201d\u2010 parity \u22655 without aPL\/APS. We examined demographics, aPL characteristics, pregnancy, and neonatal outcomes between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 42 deliveries in the study group were compared to 461 deliveries in the \u201caPL\/APS\u2010controls\u201d group and 84 deliveries of the \u201cGMP\u2010controls.\u201d Most parameters were similar across groups. However, the study group had a higher rate of obstetric APS diagnosis (64.64%\u00a0vs. 83.33%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and showed significant differences such as older maternal age, higher BMI, more polyhydramnios cases, and larger babies compared to controls (33.91\u00a0vs. 36.19, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05; 23.2\u00a0vs. 28.89, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02; 3.68\u00a0vs. 11.9, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01; and 2.17\u00a0vs. 14.28, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings reveal that perinatal outcomes in aPL\/APS GMP women are comparable and not inferior to those in aPL\/APS women with &lt;5 pregnancies or in comparison to the general GMP population. The minor differences observed may all be related to GMP women's older age and higher BMI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.70013","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T17:54:02Z","timestamp":1730310842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnancy Outcomes in Grand Multiparity Women With Antiphospholipid Antibodies"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6365-3741","authenticated-orcid":false,"given":"Keren","family":"Zloto","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Faculty of Medical and Health Sciences School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shani","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shir","family":"Lev","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakefet","family":"Yoeli\u2010Ullman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Faculty of Medical and Health Sciences School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Niznik","sequence":"additional","affiliation":[{"name":"Clinical Immunology, Angioedema and Allergy Department The Zabludowicz Center for Autoimmune Diseases Sheba Medical Center Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Agmon\u2010Levin","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Clinical Immunology, Angioedema and Allergy Department The Zabludowicz Center for Autoimmune Diseases Sheba Medical Center Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keren","family":"Ofir","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Faculty of Medical and Health Sciences School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"A. 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