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Logistic regression, restricted cubic spline regression, and BKMR were used to investigate single, nonlinear, and combined associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study, the adjusted odds ratio (OR) of white blood cell (WBC), neutrophil (NEUT), monocyte (MONO), platelet (PLT), neutrophil\u2010to\u2010lymphocyte ratio (NLR), and systemic immune inflammation index (SII) were 2.20 (95% confidence interval [CI]: 1.43\u20133.37), 2.27 (95% CI: 1.48\u20133.48), 1.67 (95% CI: 1.09\u20132.57), 1.66 (95% CI: 1.07\u20132.58), 1.65 (95% CI: 1.08\u20132.54), and 1.89 (95% CI: 1.23\u20132.91), respectively. Nonlinear associations of WBC (cutoff level: 7.91\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \/L) and NEUT (cutoff level: 5.52\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \/L) with GDM were also observed. Furthermore, BKMR analysis showed that the risk of GDM was linked with increased levels of blood cell\u2010based inflammatory indicators.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In early pregnancy, multiple blood cell\u2010based inflammatory indicators are significantly positively correlated with the risk of GDM. Specifically, WBC and NEUT counts exhibit the most prominent association with GDM risk. Therefore, more attention should be paid to the inflammation levels of early pregnant women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.70021","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T06:22:13Z","timestamp":1733206933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Single and Joint Associations Between Blood Cell\u2010Based Inflammatory Indicator in Early Pregnancy and Risk of Gestational Diabetes Mellitus (GDM): A Prospective Cohort Study"],"prefix":"10.1111","volume":"92","author":[{"given":"Yanling","family":"Xiao","sequence":"first","affiliation":[{"name":"School of Public Health Zunyi Medical University  Zunyi Guizhou China"},{"name":"Key Laboratory of Maternal &amp; Child Health and Exposure Science of Guizhou Higher Education Institutes  Zunyi Guizhou 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