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Decidual natural killer (dNK) cells, the most abundant immune cells at the maternal\u2010fetal interface, are closely associated with preeclampsia due to abnormalities in their quantity, phenotype, and function. This review summarizes the molecular mechanisms by which dNK cells regulate extravillous trophoblast (EVT) invasion, promote uterine spiral artery remodeling, and maintain immune tolerance. Furthermore, it explores how disruptions in these mechanisms and changes in the decidual microenvironment alter dNK cell properties, driving the progression of preeclampsia. Understanding the mechanisms of dNK cells and identifying potential therapeutic targets may provide new insights for clinical intervention.<\/jats:p>","DOI":"10.1111\/aji.70033","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T11:24:43Z","timestamp":1735557883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Role of Decidual Natural Killer Cells in the Pathogenesis of Preeclampsia"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2457-681X","authenticated-orcid":false,"given":"Shuang","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlai","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"},{"name":"Department of Obstetrics and Gynecology Shandong Provincial Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313276"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.09.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06357"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0119-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179343"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.918550"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01397"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.728291"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00794.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2024.02.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa062"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00417-6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.813343"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh037"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4057"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080995"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091105"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez124"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-210310"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.12.023"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2015.04.003"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109478108"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.04.008"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2010.10.003"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.08.023"},{"issue":"87","key":"e_1_2_10_29_1","article-title":"Review: Functional Role of Uterine Natural Killer (uNK) Cells in Human Early Pregnancy Decidua","volume":"31","author":"Lash G. 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